Translational repression by RNA-binding protein TIAR

Molecular and Cellular Biology
Krystyna Mazan-MamczarzMyriam Gorospe

Abstract

The RNA-binding protein TIAR has been proposed to inhibit protein synthesis transiently by promoting the formation of translationally silent stress granules. Here, we report the selective binding of TIAR to several mRNAs encoding translation factors such as eukaryotic initiation factor 4A (eIF4A) and eIF4E (translation initiation factors), eEF1B (a translation elongation factor), and c-Myc (which transcriptionally controls the expression of numerous translation regulatory proteins). TIAR bound the 3'-untranslated regions of these mRNAs and potently suppressed their translation, particularly in response to low levels of short-wavelength UV (UVC) irradiation. The UVC-imposed global inhibition of the cellular translation machinery was significantly relieved after silencing of TIAR expression. We propose that the TIAR-mediated inhibition of translation factor expression elicits a sustained repression of protein biosynthesis in cells responding to stress.

References

Jun 1, 1992·Microbiological Reviews·W C Merrick
Feb 2, 1996·The Journal of Biological Chemistry·L M DemberP Anderson
Nov 1, 1995·Trends in Biochemical Sciences·C Y Chen, A B Shyu
Jan 6, 1999·Proceedings of the National Academy of Sciences of the United States of America·J D Keene
Jan 11, 2000·Molecular and Cellular Biology·W WangM Gorospe
Dec 21, 2000·The Journal of Cell Biology·N KedershaP Anderson
Apr 6, 2001·Cellular and Molecular Life Sciences : CMLS·C M Brennan, J A Steitz
Oct 12, 2001·Apoptosis : an International Journal on Programmed Cell Death·P Förch, J Valcárcel
Jun 11, 2002·Methods : a Companion to Methods in Enzymology·Scott A TenenbaumJack D Keene
Aug 15, 2002·Current Biology : CB·Jing DengNahum Sonenberg
Aug 29, 2002·The EMBO Journal·Georg StoecklinChristoph Moroni
Oct 17, 2002·Cell Stress & Chaperones·Paul Anderson, Nancy Kedersha
Nov 9, 2002·European Journal of Biochemistry·Gareth J Browne, Christopher G Proud
Nov 21, 2002·Biochemical Society Transactions·N Kedersha, P Anderson
Feb 13, 2003·Current Opinion in Structural Biology·Nahum Sonenberg, Thomas E Dever
Apr 22, 2003·Journal of Cellular Physiology·Annamaria BevilacquaAngelo Nicolin
Apr 26, 2003·Trends in Biochemical Sciences·Gavin S WilkieNicola K Gray
Jun 25, 2003·Proceedings of the National Academy of Sciences of the United States of America·Krystyna Mazan-MamczarzMyriam Gorospe
Oct 1, 2003·Molecular and Cellular Biology·Stefanie GalbánMyriam Gorospe
Feb 26, 2004·Proceedings of the National Academy of Sciences of the United States of America·Isabel López de SilanesMyriam Gorospe
Apr 13, 2004·Journal of Leukocyte Biology·Paul AndersonNancy Kedersha
Apr 20, 2004·Oncogene·Emmett V Schmidt
Sep 15, 2004·Trends in Genetics : TIG·Carol J Wilusz, Jeffrey Wilusz
Nov 13, 2004·The Journal of Biological Chemistry·Karthikeyan KandasamyBaby G Tholanikunnel
Apr 2, 2005·Nature Reviews. Molecular Cell Biology·Martin Holcik, Nahum Sonenberg
Apr 30, 2005·The EMBO Journal·Ashish LalMyriam Gorospe
Jun 22, 2005·The Journal of Cell Biology·Nancy KedershaPaul Anderson
Jul 21, 2005·Proceedings of the National Academy of Sciences of the United States of America·Marie-Eve BordeleauJerry Pelletier
Aug 3, 2005·BioTechniques·Krystyna Mazan-MamczarzMyriam Gorospe
Oct 18, 2005·Molecular and Cellular Biology·Isabel López de SilanesMyriam Gorospe

❮ Previous
Next ❯

Citations

May 23, 2009·Nature Reviews. Molecular Cell Biology·Paul Anderson, Nancy Kedersha
May 9, 2007·Nature Structural & Molecular Biology·Baisong LiaoGary Brewer
Mar 13, 2008·Médecine sciences : M/S·Mai Nguyen-Chi, Dominique Morello
Oct 11, 2008·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Srijata SarkarSidney Pestka
Mar 12, 2013·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Martin Carroll, Katherine L B Borden
Jun 19, 2009·Molecular Biology of the Cell·Angélica FigueroaYasuyuki Fujita
Oct 17, 2008·Molecular Biology of the Cell·Michèle Ernoult-LangeDominique Weil
Jan 15, 2011·Nucleic Acids Research·Henry S KimJacqueline A Wilce
Nov 20, 2012·Nucleic Acids Research·Christina EhlersJan Chemnitz
Mar 21, 2007·Genes & Development·Tobias M Franks, Jens Lykke-Andersen
Oct 8, 2011·Genes & Development·Christian Kroun Damgaard, Jens Lykke-Andersen
Oct 21, 2011·Genes & Development·Pavel IvanovPaul Anderson
Jul 11, 2007·Molecular and Cellular Biology·Rudolf PullmannMyriam Gorospe
Aug 8, 2007·Molecular and Cellular Biology·Henry S KimJacqueline A Wilce
Aug 24, 2011·Molecular and Cellular Biology·Kumiko TominagaMyriam Gorospe
Aug 28, 2009·Genome Biology·Raquel ReyesJosé M Izquierdo
Oct 15, 2009·Journal of Cell Science·Mariela LoschiGraciela L Boccaccio
Nov 5, 2010·PLoS Biology·Zhen WangJernej Ule
Jan 1, 2012·Current Colorectal Cancer Reports·Michelina PlaterotiLuiz O F Penalva
Mar 5, 2014·Cell Stress & Chaperones·Shannon N TessierKenneth B Storey
Oct 30, 2014·Nucleic Acids Research·Ricardo Soto-RifoThéophile Ohlmann
Mar 7, 2013·The Journal of Biological Chemistry·Naoki WatanabeYoshiki Murakumo
Sep 17, 2014·Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission·E T UluerM Sancı
Feb 14, 2012·Ageing Research Reviews·Kiyoshi MasudaKazuhito Rokutan
Apr 5, 2013·Immunological Reviews·Pavel Ivanov, Paul Anderson
Jul 1, 2010·Wiley Interdisciplinary Reviews. RNA·Deborah J StumpoPerry J Blackshear
May 3, 2014·Wiley Interdisciplinary Reviews. RNA·Dirk H OstareckAntje Ostareck-Lederer
Aug 8, 2006·Biochemical and Biophysical Research Communications·José M Izquierdo
Jun 4, 2015·Cell Cycle·Carmen Sánchez-Jiménez, José M Izquierdo

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.