Translational research in retinal vascular disease. An approach

Acta Ophthalmologica
T Bek

Abstract

The clinical presentation of the most frequent vision threatening retinal diseases is dominated by lesions indicating that disturbances in retinal blood flow are involved in the pathogenesis of these diseases. The present review describes the experience from a translational strategy pursued to investigate retinal vascular diseases with diabetic retinopathy as the main object. The normal regulation of retinal blood flow is investigated in porcine retinal vessels in vitro and ex vivo. Subsequently, the in vitro findings are translated to clinical studies in normal persons in vivo, and it is investigated whether the mechanisms are disturbed in retinal vascular disease. This is followed by clinical intervention studies on these diseases. The approach has been used to investigate pressure autoregulation, metabolic autoregulation and vasomotion in retinal vessels. The investigations have shown that retinal vascular tone can be regulated by receptor-specific agonists and antagonists to vasoactive compounds such as purines, prostaglandins and nitric oxide synthesis and that the vasoactive effects can be modulated by the concentration and the mode of administration of these compounds. Additionally, it has been shown that retinal precapi...Continue Reading

References

Jul 1, 1990·The British Journal of Ophthalmology·T Bek, H Lund-Andersen
Jun 1, 1997·Acta Ophthalmologica Scandinavica·T Bek
Oct 6, 2001·Progress in Retinal and Eye Research·L Schmetterer, K Polak
May 16, 2003·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·A M JoussenB Kirchhof
May 17, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Guido T DornerLeopold Schmetterer
Jun 5, 2003·Acta Ophthalmologica Scandinavica·Anders HessellundToke Bek
Jun 26, 2003·Investigative Ophthalmology & Visual Science·Elzbieta PolskaLeopold Schmetterer
Oct 1, 1954·The British Journal of Ophthalmology·I C MICHAELSOND KERTESZ
Oct 17, 2003·Current Eye Research·Peter JeppesenToke Bek
Jun 19, 2004·The British Journal of Ophthalmology·G GarhöferG T Dorner
Jul 20, 2004·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Peter JeppesenToke Bek
Mar 16, 2006·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Christian Alcaraz FrederiksenToke Bek
Apr 28, 2006·Acta Ophthalmologica Scandinavica·Anders HessellundToke Bek
May 23, 2006·Current Eye Research·Anders HessellundToke Bek
May 10, 2007·Acta Ophthalmologica Scandinavica·Peter JeppesenToke Bek
Aug 31, 2007·Diabetes Care·Aleksandra MandeckaUlrich Alfons Müller
Feb 13, 2008·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Toke BekPeter Jeppesen
May 2, 2008·Progress in Retinal and Eye Research·Constantin J PournarasEinar Stefansson
Sep 2, 2008·Investigative Ophthalmology & Visual Science·Maria Skytte TorringToke Bek
May 1, 2009·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Martin HammerJürgen Strobel
Jul 31, 2009·Diabetes Care·Thanh T NguyenTien Y Wong
Aug 7, 2010·Investigative Ophthalmology & Visual Science·Mikkel Wölck MisfeldtToke Bek
Oct 5, 2010·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Toke Bek
Nov 12, 2010·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Peter Skov JensenToke Bek
Feb 2, 2011·Investigative Ophthalmology & Visual Science·Amélie Lecleire-ColletPascale Massin
Apr 27, 2011·Acta Physiologica·C AalkjærV Matchkov
Jun 24, 2011·Investigative Ophthalmology & Visual Science·Doreen SchmidlLeopold Schmetterer
Jul 16, 2011·Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi·Eun Bok Baek, Sung Joon Kim

❮ Previous
Next ❯

Citations

May 28, 2019·Indian Journal of Ophthalmology·Shreyas TemkarVatsalya Venkatraman
Jun 7, 2020·Journal of Clinical Medicine·Jacqueline ChuaLeopold Schmetterer
Mar 17, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·J K AkintundeL O Ajisafe

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde
Line Petersen, T Bek
Indian Journal of Ophthalmology
I S Jain
Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie
Musa Yasin KayaToke Bek
© 2022 Meta ULC. All rights reserved