Translational research into sexual disorders: pharmacology and genomics

European Journal of Pharmacology
Johnny S W ChanRonald S Oosting

Abstract

The existence of sexual dysfunctions in men, including premature and retarded ejaculation poses challenges to develop translational models in rats that may help in improving treatment and delineate the neural mechanisms of action. Most of our current understanding of the neurobiology, neuroanatomy and psychopharmacology of sexual behavior and ejaculatory function has been derived from preclinical studies in the rat. When large populations of male rats are tested on sexual activity during four successive tests, over time individual rats display a very stable sexual behavior that is either slow, normal or fast as characterized by the number of ejaculations performed. These sexual endophenotypes are postulated as rat counterparts of premature (fast rats) or retarded ejaculation (slow rats). Psychopharmacology in these endophenotypes may help to delineate the underlying mechanisms and pathology. This is illustrated by the effects of serotonergic antidepressants and serotonergic compounds on sexual and ejaculatory behavior of rats. Further unravelling of sexual endophenotypes may benefit from the use of chromosomal substitution strains in mice that enable the localization of relevant chromosomal areas and genes involved in ejaculati...Continue Reading

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Citations

Oct 17, 2013·Pharmacology, Biochemistry, and Behavior·Elisabeth Y BijlsmaRonald S Oosting
May 3, 2014·International Journal of Impotence Research·M E Hueletl-SotoG Rodríguez-Manzo
Oct 14, 2011·The Journal of Sexual Medicine·Jacques Buvat
Sep 3, 2010·The Journal of Sexual Medicine·Eelke M S SnoerenRonald S Oosting
Oct 5, 2010·Progress in Neuro-psychopharmacology & Biological Psychiatry·J D A OlivierJ R Homberg
Mar 17, 2009·European Journal of Pharmacology·Johnny S W ChanBerend Olivier
Dec 3, 2014·European Journal of Pharmacology·Berend Olivier
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Apr 17, 2020·Frontiers in Behavioral Neuroscience·Diana Carolina Esquivel-FrancoJocelien D A Olivier
Jan 21, 2020·Frontiers in Behavioral Neuroscience·Michal BialyTymoteusz Zera
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