Translational treatment of aphasia combining neuromodulation and behavioral intervention for lexical retrieval: implications from a single case study

Frontiers in Human Neuroscience
Elizabeth E Galletta, Amy Vogel-Eyny

Abstract

Transcranial direct current stimulation (tDCS), a non-invasive method of brain stimulation, is an adjunctive research-therapy for aphasia. The concept supporting translational application of tDCS is that brain plasticity, facilitated by language intervention, can be enhanced by non-invasive brain stimulation. This study combined tDCS with an ecologically focused behavioral approach that involved training nouns and verbs in sentences. A 43-year-old, right-handed male with fluent-anomic aphasia who sustained a single-left-hemisphere-temporal-parietal stroke was recruited. Instrumentation included the Soterix Medical 1 × 1 Device. Anodal tDCS was applied over Broca's area. Behavioral materials included: sentence production, naming in the sentence context, and implementation of a social-conversational-discourse treatment. The independent variable of this crossover case-study was tDCS, and the dependent variables were language and quality-of-life measures. In each session the subject received language treatment with the first 20 minutes additionally including tDCS. Performance in naming nouns and verbs in single words and sentences were obtained. Verb production in the sentence context increased after active anodal tDCS and speech-l...Continue Reading

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Citations

Jan 28, 2020·Journal of the International Neuropsychological Society : JINS·Elodie GuillouëtSophie Charveriat
Aug 30, 2017·Expert Review of Neurotherapeutics·Sadhvi Saxena, Argye E Hillis
Sep 29, 2020·Frontiers in Neurology·Shereen J MatarMarousa Pavlou

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Aphasia

Aphasia affects the ability to process language, including formulation and comprehension of language and speech, as well as the ability to read or write. Here is the latest research on aphasia.