Translesion polymerase genes polymorphisms and haplotypes influence survival of osteosarcoma patients

Omics : a Journal of Integrative Biology
Katja GoričarVita Dolžan

Abstract

Cytotoxic activity of most chemotherapeutic agents is based on their ability to induce DNA damage. Interstrand crosslinks are among the most detrimental forms of DNA damage as both DNA strands are affected. As translesion polymerases participate in their repair, they may be important for response to chemotherapeutic agents that induce such lesions, including commonly used cisplatin. Altered expression of translesion polymerase genes REV1 and REV3L may modify sensitivity to cisplatin. As osteosarcoma patients are commonly treated with cisplatin-based chemotherapy, our aim was to investigate if REV1 and REV3L polymorphisms influence survival of osteosarcoma patients treated with cisplatin-based chemotherapy. We determined the genotypes of common functional tag REV1 and REV3L polymorphisms in 66 osteosarcoma patients. Cox regression was used for survival analysis. Carriers of at least one polymorphic REV1 rs3087403 allele had significantly shorter EFS and overall survival (OS) (p = 0.004; HR = 3.79; 95%CI = 1.53-9.35 and p < 0.001; HR = 4.44; 95%CI = 1.92-10.27, respectively). Combination of REV1 rs3087403 and REV3L rs462779 polymorphisms was also significantly associated with shorter OS (ptrend<0.001) and shorter EFS (ptrend = 0....Continue Reading

References

Dec 21, 2004·International Journal of Cancer. Journal International Du Cancer·Tokuki SakiyamaJun Yokota
Jul 13, 2006·Expert Review of Anticancer Therapy·Alexander J Chou, Richard Gorlick
May 13, 2008·European Journal of Epidemiology·Xiaohong HeHuaizeng Chen
Jun 16, 2009·Pharmacogenetics and Genomics·Sharon MarshRuss B Altman
Jun 26, 2010·Pharmacogenetics and Genomics·Carolina Salinas-SouzaSilvia R C de Toledo
Oct 15, 2010·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J Ritter, S S Bielack
Nov 12, 2010·Proceedings of the National Academy of Sciences of the United States of America·Jason DolesMichael T Hemann
Jan 25, 2011·Nature Reviews. Cancer·Sabine S LangeRichard D Wood
Sep 20, 2011·Nucleic Acids Research·Shilpy SharmaChristine E Canman
Sep 14, 2012·Frontiers in Genetics·Nick M Makridakis, Juergen K V Reichardt
Oct 16, 2012·Environmental and Molecular Mutagenesis·Shilpy Sharma, Christine E Canman
Oct 27, 2012·Asian Pacific Journal of Cancer Prevention : APJCP·Ting HaoGang Wang
Jan 16, 2013·Asian Pacific Journal of Cancer Prevention : APJCP·Li-Min YangCui-Fen Bao
Feb 6, 2013·Cancer Biology & Therapy·Derek Woods, John J Turchi
Apr 1, 2015·Journal of Medical Biochemistry·Katja GoričarVita Dolžan

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Citations

Jun 30, 2016·Drug Discovery Today·Hanneke I VosDunja Maroeska W M Te Loo
Oct 4, 2017·Scientific Reports·Nima Borhan FakouriLene Juel Rasmussen
Mar 13, 2020·Genes and Environment : the Official Journal of the Japanese Environmental Mutagen Society·Megumi SasataniKenji Kamiya
Oct 14, 2020·Biochemistry. Biokhimii︠a︡·E S ShilkinA V Makarova
Nov 14, 2020·Journal of Cellular Physiology·Priyanka SahaAmit K Srivastava

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Methods Mentioned

BETA
genotyping

Software Mentioned

SPSS Statistics
KASPar
Thesias

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