Translocase of inner mitochondrial membrane 44 alters the mitochondrial fusion and fission dynamics and protects from type 2 diabetes

Metabolism: Clinical and Experimental
Yu WangJun Wada

Abstract

In obesity and type 2 diabetes, the impairment of mitochondrial function in white adipose tissue (WAT) is linked to a reduction in whole body insulin sensitivity. Timm44 is upregulated in the kidneys of streptozotocin-induced diabetic mice. In the inner mitochondrial membrane, Timm44 anchors mitochondrial heat-shock protein 70 (mtHsp70) to the translocase of inner mitochondrial membrane 23 (TIM23) complex and facilitates the import of mitochondria-targeted preproteins into the mitochondrial matrix dependent on the inner membrane potential and ATP hydrolysis on ATPase domain of mtHsp70. We generated the aP2-promoter driven Timm44 transgenic (Tg) mouse model and investigated whether Timm44 Tg mice fed high-fat/high-sucrose (HFHS) chow are protected from type 2 diabetes and obesity. The body weight of aP2-promoter driven Timm44 Tg mice was lower than that of wild type mice, and insulin sensitivity was greater in Timm44 Tg mice than in wild type mice. Although WAT weight was not altered in Timm44 Tg mice fed HFHS chow, adipocyte size was reduced, and mitochondrial fusion associated with decreased expression of fission genes, such as Dnm1l and Fis1, was observed. In addition, when fed standard (STD) chow, the expressions of the fusi...Continue Reading

References

Feb 21, 1998·Proceedings of the National Academy of Sciences of the United States of America·J Wada, Y S Kanwar
Jan 17, 2003·Molecular and Cellular Biology·Leanne Wilson-FritchSilvia Corvera
Sep 10, 2004·Molecular Biology of the Cell·Yang-ja LeeRichard J Youle
Nov 3, 2004·The Journal of Clinical Investigation·Leanne Wilson-FritchSilvia Corvera
Oct 6, 2005·The Journal of Clinical Endocrinology and Metabolism·Iwona BogackaSteven R Smith
Sep 11, 2007·Nature Cell Biology·Martin van der LaanPeter Rehling
Sep 21, 2007·The Journal of Biological Chemistry·Olga Slutsky-LeidermanAbdussalam Azem
Jul 11, 2008·Cell·David J PagliariniVamsi K Mootha
Jan 16, 2009·Molecular Biology of the Cell·Dejana MokranjacWalter Neupert
Aug 26, 2009·The International Journal of Biochemistry & Cell Biology·Antonio ZorzanoManuel Palacín
May 10, 2011·Molecular Biology of the Cell·Zhongyan ZhangHiromi Sesaki
Feb 7, 2012·Trends in Endocrinology and Metabolism : TEM·Kelsey H Fisher-Wellman, P Darrell Neufer
Mar 20, 2012·Proceedings of the National Academy of Sciences of the United States of America·David SebastiánAntonio Zorzano
Mar 23, 2012·The New England Journal of Medicine·Werner J H KoopmanJan A M Smeitink
Jul 13, 2012·Trends in Endocrinology and Metabolism : TEM·Christine M Kusminski, Philipp E Scherer
Aug 9, 2012·Antioxidants & Redox Signaling·Naotada IshiharaKatsuyoshi Mihara
Sep 1, 2012·Science·Richard J Youle, Alexander M van der Bliek
Dec 7, 2013·The New England Journal of Medicine·Stephen L Archer

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Citations

Sep 4, 2016·Cell and Tissue Research·Keren Demishtein-Zohary, Abdussalam Azem
Feb 13, 2017·Cardiovascular Drugs and Therapy·Sang-Bing OngDerek John Hausenloy
Sep 7, 2019·American Journal of Physiology. Heart and Circulatory Physiology·Ivan MerdzoDavid W Busija
May 11, 2018·Current Hypertension Reports·Natalia Jorgelina PradoEmiliano Raúl Diez
Sep 10, 2020·Cell Biochemistry and Biophysics·Xiaohui YuMing Lu
Feb 16, 2021·The Journal of Clinical Investigation·Jennifer M PetrosinoFederica Accornero
May 24, 2021·Molecular Biology Reports·Bhoomika SherkhaneShashi Bala Singh
Jun 3, 2021·Biomolecules·Liang-Jun Yan

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