Translocation (12;14) and other chromosome abnormalities in squamous cell carcinoma of the tongue.

European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
Esther ManorLipa Bodner

Abstract

Tongue squamous cell carcinoma (SCC) has an increasing incidence, a high morbidity rate, and a 50% 5-year survival rate. The prognosis of tongue SCC is poor compared to SCC originating at other sites in the oral cavity, because they represent different biological subentities. Cytogenetic studies of head and neck SCC showed more losses than gains of various chromosomes or chromosomal segments. Among the frequent alterations there are losses of -4, -10, -13, -14, -18, -19, -21, -22, gains of +7, +8, +9, +16, +18, +20, and isochromosomes i(1q), i(3q), i(5p), i(8q). We are unaware of cytogenetic reports describing t(12;14) in tongue SCC. This is a cytogenetic study of SCC of the tongue. Tongue biopsy tissue was minced and cultured in RPMI-1640 medium. Cells were fixed and stained, and cytogenetic analysis performed according to standard procedures. A clone with t(12;14) along with other random numerical chromosomal changes was found in a case of tongue SCC. The significance of t(12;14) in diagnosis or prognosis is not clear and should be further examined. Karyotyping of more tongue SCC cases will expand the knowledge regarding chromosomal aberrations in SCC and thus might shed light on the significance of t(12;14) shown in this study.

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Citations

Aug 28, 2012·Case Reports in Dentistry·Esther ManorLipa Bodner
Dec 3, 2011·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Esther ManorLipa Bodner
May 11, 2012·The British Journal of Oral & Maxillofacial Surgery·Esther ManorLipa Bodner
Jun 15, 2012·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Esther ManorLipa Bodner
Jan 10, 2012·The British Journal of Oral & Maxillofacial Surgery·Esther ManorLipa Bodner
Aug 13, 2011·The British Journal of Oral & Maxillofacial Surgery·Esther ManorLipa Bodner
Dec 16, 2010·Cancer Genetics and Cytogenetics·Maria Angeles Jimenez-SousaJose Miguel Garcia Sagredo
Nov 16, 2010·The British Journal of Oral & Maxillofacial Surgery·Lipa BodnerPeter A Brennan

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