Translocation (3;8)(q26;q24): a recurrent chromosomal abnormality in myelodysplastic syndrome and acute myeloid leukemia

Cancer Genetics and Cytogenetics
Pei LinLynne V Abruzzo

Abstract

We identified a reciprocal translocation between chromosomes 3 and 8, with breakpoints at bands 3q26 and 8q24, in five patients with myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML). The t(3;8)(q26;q24) was the sole cytogenetic aberration in two patients, was associated with trisomy 13 in one patient, and occurred with monosomy 7 in two patients. In three patients, the AML or MDS developed 36, 52, and 57 months following chemotherapy for soft tissue sarcoma, mantle cell lymphoma, and diffuse large B-cell lymphoma, respectively; in these three patients, the neoplasms were considered to be therapy-related. All five patients displayed marked trilineage dysplasia and variable degrees of cytopenias, with marked thrombocytosis noted in one patient and a normal platelet count in another patient. All patients were treated with combination chemotherapy; at writing, four were still alive and one had died during a follow-up period ranging from 1 to 16 months. We conclude that the t(3;8)(q26;q24) is a recurrent translocation associated with therapy-related MDS/AML or de novo AML, and is frequently associated with monosomy 7.

References

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Citations

Jan 9, 2014·Leukemia & Lymphoma·Xiangdong XuHuan-You Wang
Jan 13, 2016·Annals of Hematology·Yasushi KubotaShinya Kimura
Aug 12, 2009·Cancer Genetics and Cytogenetics·Pei LinLynne V Abruzzo
Jul 16, 2010·International Journal of Laboratory Hematology·C C YinC E Bueso-Ramos
Aug 19, 2007·Cancer Genetics and Cytogenetics·Patrick A LennonPei Lin
Nov 30, 2005·Gene·Giuseppina NuciforaVitalyi Senyuk
Apr 27, 2013·Journal of Pediatric Hematology/oncology·Xiayuan LiangDouglas K Graham
Sep 30, 2021·Nature Communications·Sophie OttemaRuud Delwel

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