Translocation, biotransformation-related degradation, and toxicity assessment of polyvinylpyrrolidone-modified 2H-phase nano-MoS2

Nanoscale
Linqiang MeiYuliang Zhao

Abstract

Nano-MoS2 has been extensively investigated in materials science and biomedicine. However, the effects of different methods of exposure on their translocation, biosafety, and biotransformation-related degradability remain unclear. In this study, we combined the advantages of synchrotron radiation (SR) X-ray absorption near-edge structure (XANES) and high-resolution single-cell SR transmission X-ray microscopy (SR-TXM) with traditional analytical techniques to investigate translocation, precise degraded species/ratio, and correlation between the degradation and toxicity levels of polyvinylpyrrolidone-modified 2H-phase MoS2 nanosheets (MoS2-PVP NSs). These NSs demonstrated different biodegradability levels in biomicroenvironments with H2O2, catalase, and human myeloperoxidase (hMPO) (H2O2 < catalase < hMPO). The effects of NSs and their biodegraded byproducts on cell viability and 3D translocation at the single-cell level were also assessed. Toxicity and translocation in mice via intravenous (i.v.), intraperitoneal (i.p.), and intragastric (i.g.) administration routes guided by fluorescence (FL) imaging were investigated within the tested dosage. After i.g. administration, NSs accumulated in the gastrointestinal organs and were e...Continue Reading

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Apr 1, 2020·Chembiochem : a European Journal of Chemical Biology·Dongqing MaWenyan Yin
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Mar 3, 2021·ACS Nano·Carlos Sanchez-CanoWolfgang J Parak

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Methods Mentioned

BETA
X-ray
transmission electron microscopy
imaging technique
scanning electron microscopy
AFM
atomic force microscopy
dynamic light scattering

Software Mentioned

Avizo
TXM 3Dviewer
XANES
TXM Controller
TXM Reconstructor
Athena

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