Translocation of chicken heart apocytochrome c and its mutants (C17S, H18D) across mitochondrial membrane

Science in China. Series C, Life Sciences
Y ZhuF Y Yang

Abstract

The dependence of import of chicken heart apocytochrome c on its transformation to holoform by heme attachment was studied. Results showed that there was no difference in the translocation of apocytochrome c across the mitochondrial membrane in the presence or absence of hemin + dithionite. Furthermore, two heme unattached mutants (H18D. C17S) were prepared, which could still be accumulated in mitochondria, but their import velocity was obviously reduced.

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Citations

Dec 7, 2007·Journal of Clinical Nursing·Robert JenkinsRuth Northway

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