Translocation of flexible polymersomes across pores at the nanoscale

Biomaterials Science
Carla PegoraroGiuseppe Battaglia

Abstract

Hierarchical biological systems such as tissues and organs are often characterised by highly crowded and packed environments with nanoscopic interconnections between them. Engineering nanovectors that can penetrate and diffuse across these is critical to ensure enhanced delivery and targeting. Here we demonstrate that flexible polymeric vesicles, known as polymersomes, enable the translocation of large macromolecules across both synthetic and biological porous systems. We compare the translocation across narrow pores of different polymersome formulations. We demonstrate that effective translocation depends on the right combination of mechanical properties and surface lubrication. We prove that with the effect of external gradients (e.g. osmotic pressure, capillarity, hydration, etc.) polymersomes can translocate across pores with diameters one order of magnitude smaller without breaking. We demonstrate that these properties are essential to develop effective tissue penetration and show polymersome mediated transdermal delivery of large macromolecules such as dextran and antibodies using human ex vivo skin.

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Citations

Jun 11, 2015·Scientific Reports·Gavin FullstoneGiuseppe Battaglia
Jun 9, 2016·Scientific Reports·James D RobertsonGiuseppe Battaglia
Jun 21, 2017·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Abdul Khaliq Elzhry ElyafiJonathan P Salvage
Mar 16, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·James D RobertsonStephen A Renshaw
Jun 5, 2018·Nanomaterials·Alexsandra Conceição ApolinárioCarlota de Oliveira Rangel-Yagui
Feb 18, 2016·Molecular Cancer Therapeutics·Lorena Simón-GraciaTambet Teesalu

Related Concepts

Environment
Polymers
Dextran
Macromolecule
Organ
Surface
Pharmacologic Substance
In Vivo
Nuclear Translocation
Vesicle

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