Translocation of flexible polymersomes across pores at the nanoscale

Biomaterials Science
Carla PegoraroGiuseppe Battaglia


Hierarchical biological systems such as tissues and organs are often characterised by highly crowded and packed environments with nanoscopic interconnections between them. Engineering nanovectors that can penetrate and diffuse across these is critical to ensure enhanced delivery and targeting. Here we demonstrate that flexible polymeric vesicles, known as polymersomes, enable the translocation of large macromolecules across both synthetic and biological porous systems. We compare the translocation across narrow pores of different polymersome formulations. We demonstrate that effective translocation depends on the right combination of mechanical properties and surface lubrication. We prove that with the effect of external gradients (e.g. osmotic pressure, capillarity, hydration, etc.) polymersomes can translocate across pores with diameters one order of magnitude smaller without breaking. We demonstrate that these properties are essential to develop effective tissue penetration and show polymersome mediated transdermal delivery of large macromolecules such as dextran and antibodies using human ex vivo skin.


Mar 1, 1975·The Journal of Investigative Dermatology·T J Franz
Oct 1, 1995·Physical Review. E, Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics·G Gompper, D M Kroll
May 15, 1999·Science·B M DischerD A Hammer
Oct 8, 1999·Biophysical Journal·D K Lubensky, D R Nelson
Apr 19, 2003·Science·Sumeet Jain, Frank S Bates
Sep 2, 2004·Biophysical Journal·Matthias WeissTommy Nilsson
Mar 19, 2005·Langmuir : the ACS Journal of Surfaces and Colloids·H BermúdezD E Discher
Jun 16, 2005·Journal of the American Chemical Society·Giuseppe Battaglia, Anthony J Ryan
Dec 22, 2005·Journal of the American Chemical Society·Jianzhong DuSteven P Armes
Feb 24, 2006·Angewandte Chemie·Giuseppe Battaglia, Anthony J Ryan
Mar 18, 2006·International Journal for Parasitology·Kwang Sik Kim
May 26, 2006·The Journal of Physical Chemistry. B·Giuseppe Battaglia, Anthony J Ryan
Jun 29, 2006·Physical Review Letters·Joanne Klein WolterinkDebabrata Panja
Jan 2, 2007·Journal of Controlled Release : Official Journal of the Controlled Release Society·F J VerbaanJoke A Bouwstra
Jan 10, 2008·Proceedings of the National Academy of Sciences of the United States of America·Ren-Huai HuangJ Evan Sadler
Jun 24, 2008·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·G M El MaghrabyA C Williams
Dec 4, 2008·Faraday Discussions·Hannah LomasGiuseppe Battaglia
Jan 21, 2009·Cancer Metastasis Reviews·Peter Friedl, Katarina Wolf
Jun 10, 2010·Chemical Record : an Official Publication of the Chemical Society of Japan ... [et Al.]·Motoyasu Kobayashi, Atsushi Takahara
Jul 21, 2010·Developmental Cell·Chris D Madsen, Erik Sahai
Jan 29, 2011·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·A GilletG Piel
Dec 21, 2011·Physical Review Letters·Jack A CohenRamin Golestanian
Feb 16, 2012·Nanoscale·Carla PegoraroGiuseppe Battaglia
Jul 10, 2012·Proceedings of the National Academy of Sciences of the United States of America·Dan ZhengAmy S Paller


Jun 11, 2015·Scientific Reports·Gavin FullstoneGiuseppe Battaglia
Jun 9, 2016·Scientific Reports·James D RobertsonGiuseppe Battaglia
Jun 21, 2017·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Abdul Khaliq Elzhry ElyafiJonathan P Salvage
Mar 16, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·James D RobertsonStephen A Renshaw
Jun 5, 2018·Nanomaterials·Alexsandra Conceição ApolinárioCarlota de Oliveira Rangel-Yagui
Feb 18, 2016·Molecular Cancer Therapeutics·Lorena Simón-GraciaTambet Teesalu

Related Concepts

Pharmacologic Substance
In Vivo
Nuclear Translocation

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Synthetic Genetic Array Analysis

Synthetic genetic arrays allow the systematic examination of genetic interactions. Here is the latest research focusing on synthetic genetic arrays and their analyses.

Congenital Hyperinsulinism

Congenital hyperinsulinism is caused by genetic mutations resulting in excess insulin secretion from beta cells of the pancreas. Here is the latest research.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Epigenetic Memory

Epigenetic memory refers to the heritable genetic changes that are not explained by the DNA sequence. Find the latest research on epigenetic memory here.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Femoral Neoplasms

Femoral Neoplasms are bone tumors that arise in the femur. Discover the latest research on femoral neoplasms here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

© 2021 Meta ULC. All rights reserved