Translocation of Oligonucleotide-Oligosaccharide Complexes into Cells of the Brain

Doklady. Biochemistry and Biophysics
N N DygaloD A Lanshakov

Abstract

Irradiation of a mixture of oligonucleotides with dextran resulted in the formation of a complex that is detected by a decelerated migration of an irradiated sample in electrophoretic gel compared to a non-irradiated one. When injected into the brain of neonatal rats, the formed complex penetrated into the cells 3 times easier compared to the original oligonucleotide, thus indicating that the use of radiation crosslinking of oligonucleotides with oligosaccharides is promising to enhance the efficiency of delivery of gene-targeted oligonucleotide drugs into cells.

References

Jan 6, 2009·Annals of the New York Academy of Sciences·Nikolay N DygaloGalina T Shishkina
Feb 14, 2016·Neurobiology of Disease·Dmitriy A LanshakovNikolay N Dygalo
Apr 17, 2016·Nucleic Acids Research·Rudolph L Juliano
Dec 27, 2016·Current Topics in Medicinal Chemistry·Mehmet S ErogluMuge Sennaroglu Bostan

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