PMID: 6781778Jan 19, 1981

Translocation t (8; 21) and acute granulocytic leukemia: interpretation of normal mitoses

Comptes rendus des séances de l'Académie des sciences. Série III, Sciences de la vie
R BergerG Flandrin


Cytological and cytogenetic studies of nine acute granulocytic leukemia with t (8; 21) translocation were performed from the same bone marrow and blood cell samples. It was shown that the chromosome abnormality was restricted to leukemic cells and that normal metaphases were erythroblast mitoses. Using cell cultures in which only or mainly leukemic cells were able to divide permits easier detection of chromosomal aberrations. These results led us to postulate an inhibitory role of leukemic cells on the division of normal granulocytic cells.

Related Concepts

Cell Division Phases
M Phase, Mitotic
Chromosomal Translocation
Acute Myeloid Leukemia, M1

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Acute Myeloid Leukemia

Acute myeloid leukemia (AML) is a clinically and genetically heterogeneous disease with approximately 20,000 cases per year in the United States. AML also accounts for 15-20% of all childhood acute leukemias, while it is responsible for more than half of the leukemic deaths in these patients. Here is the latest research on this disease.

AML: Role of LSD1 by CRISPR (Keystone)

Find the latest rersearrch on the ability of CRISPR-Cas9 mutagenesis to profile the interactions between lysine-specific histone demethylase 1 (LSD1) and chemical inhibitors in the context of acute myeloid leukemia (AML) here.