Translocation t(12;21) is related to in vitro cellular drug sensitivity to doxorubicin and etoposide in childhood acute lymphoblastic leukemia.

Blood
Britt-Marie FrostGudmar Lönnerholm

Abstract

The t(12;21) (p13;q22) translocation resulting in ETV6/RUNX1 (previously named TEL/AML1) gene fusion is present in about 25% of children with precursor B-lineage acute lymphoblastic leukemia (B-ALL). We successfully tested 275 precursor B-ALL samples from children aged 1 to 17 years to determine the relation between t(12;21) and in vitro cellular drug resistance, measured by the fluorometric microculture cytotoxicity assay (FMCA). Samples from 83 patients (30%) were positive for t(12;21). The ETV6/RUNX1(+) samples were significantly more sensitive than ETV6/RUNX1(-) samples to doxorubicin, etoposide, amsacrine, and dexamethasone, whereas the opposite was true for cytarabine. After matching for unevenly distributed patient characteristics, that is, excluding patients with high hyperdiploidy (> 51 chromosomes), t(9; 22), t(1;19), or 11q23 rearrangement, the ETV6/RUNX1(+) samples remained significantly more sensitive to doxorubicin (P = .001) and etoposide (P = .001). For the other drugs tested (amsacrine, cytarabine, dexamethasone, prednisolone, vincristine, 6-thioguanine, and 4-hydroperoxy-cyclophosphamide), no significant difference in cellular drug sensitivity was found. In conclusion, we found that the presence of the t(12;21...Continue Reading

Citations

Oct 12, 2012·Cancer Chemotherapy and Pharmacology·Oystein BruserudKimberley Joanne Hatfield
Nov 12, 2009·Future Oncology·Carlos A Castaneda, Henry L Gomez
Dec 23, 2014·Leukemia & Lymphoma·Line Groth-PedersenKjeld Schmiegelow
Feb 2, 2010·Hematology/oncology Clinics of North America·Rob Pieters, William L Carroll
Feb 5, 2008·Pediatric Clinics of North America·Rob Pieters, William L Carroll
Feb 5, 2008·British Journal of Haematology·Erik ForestierUNKNOWN NOPHO Leukaemia Cytogenetic Study Group (NLCSG)
Oct 15, 2009·Hematology/oncology Clinics of North America·Syed A AbutalibWendy Stock
Nov 5, 2004·Leukemia·B M FrostUNKNOWN Nordic Society for Paediatric Haematology and Oncology
Nov 25, 2004·Hematology·Ching-Hon PuiCharlotte M Niemeyer
Mar 3, 2009·Expert Opinion on Emerging Drugs·Klaus PodarKenneth C Anderson
Nov 18, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Andrea InthalE Renate Panzer-Grümayer

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Related Papers

European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
Rolf Larsson, Peter Nygren
European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
H FridborgRolf Larsson
© 2022 Meta ULC. All rights reserved