PMID: 9646030Jul 1, 1998Paper

Translocation (X;18) in a biphasic synovial sarcoma with morphologic features of neural differentiation

Diagnostic Molecular Pathology : the American Journal of Surgical Pathology, Part B
R NogueraA Llombart-Bosch

Abstract

The authors report a recurred neoplasm showing distinctive histologic, immunophenotypic, and ultrastructural features characteristic of biphasic synovial sarcoma with neural differentiation. The features include areas with a growth pattern of densely packed spindle cells in irregularly intersecting, broad fascicles, diffuse vimentin and HBA 71 immunoreactivity, expression of S-100 protein, and other neural markers. Moreover, areas with glandular structures and cellular expression of cytokeratin and epithelial membrane antigen were noted. Additionally, areas of neural-like growth pattern were positive for neuron-specific enolase, HNK-1, and protein gene product 9.5. Furthermore, cytogenetic analysis, two-color interphase fluorescence in situ hybridization, and reverse transcription polymerase chain reaction demonstrated the reciprocal translocation between chromosomes X and 18 associated with the different subtypes of tumor cells. The establishment and characterization of the tumor cell line are detailed. This cell line retains the distinct morphologic and genetic characteristics of the original biphasic synovial sarcoma with neural differentiation.

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Citations

Mar 14, 2002·Cancer Genetics and Cytogenetics·Avery A Sandberg, Julia A Bridge
Dec 7, 2000·Genes, Chromosomes & Cancer·N R dos SantosA G van Kessel
May 28, 2004·Diagnostic Molecular Pathology : the American Journal of Surgical Pathology, Part B·Noguera RosaLlombart-Bosch Antonio
Sep 16, 2009·Applied Immunohistochemistry & Molecular Morphology : AIMM·Jefferson Terry, Torsten Nielsen
Dec 6, 2000·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·M J O'SullivanJ D Pfeifer
Jan 6, 2001·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·M J O'SullivanJ D Pfeifer
Sep 8, 2000·Diagnostic Molecular Pathology : the American Journal of Surgical Pathology, Part B·A Llombart-BoschA Peydró-Olaya
Jan 23, 1999·Diagnostic Molecular Pathology : the American Journal of Surgical Pathology, Part B·A MezzelaniS Pilotti
May 11, 2002·Laboratory Investigation; a Journal of Technical Methods and Pathology·Elena TamboriniSilvana Pilotti
Dec 3, 2002·The American Journal of Surgical Pathology·Silvana Pilotti, Marco A Pierotti
Dec 12, 2001·Medical Hypotheses·Z ZhangF P Xie
Jun 3, 2000·Archives of Pathology & Laboratory Medicine·R VangL D Cooley

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