Transmembrane adaptor proteins in the high-affinity IgE receptor signaling.

Frontiers in Immunology
P DráberLubica Dráberová

Abstract

Aggregation of the high-affinity IgE receptor (FcεRI) initiates a cascade of signaling events leading to release of preformed inflammatory and allergy mediators and de novo synthesis and secretion of cytokines and other compounds. The first biochemically well defined step of this signaling cascade is tyrosine phosphorylation of the FcεRI subunits by Src family kinase Lyn, followed by recruitment and activation of spleen tyrosine kinase (Syk). Activity of Syk is decisive for the formation of multicomponent signaling assemblies, the signalosomes, in the vicinity of the receptors. Formation of the signalosomes is dependent on the presence of transmembrane adaptor proteins (TRAPs). These proteins are characterized by a short extracellular domain, a single transmembrane domain, and a cytoplasmic tail with various motifs serving as anchors for cytoplasmic signaling molecules. In mast cells five TRAPs have been identified [linker for activation of T cells (LAT), non-T cell activation linker (NTAL), linker for activation of X cells (LAX), phosphoprotein associated with glycosphingolipid-enriched membrane microdomains (PAG), and growth factor receptor-bound protein 2 (Grb2)-binding adaptor protein, transmembrane (GAPT)]; engagement of f...Continue Reading

Citations

May 6, 2015·European Journal of Pharmacology·Petr DraberToshiaki Kawakami
Jun 1, 2016·Frontiers in Cell and Developmental Biology·Ivana Halova, Petr Draber
Oct 4, 2016·International Immunopharmacology·Jatinder SinghDhandeep Singh
Jun 23, 2020·Journal of Ophthalmology·Xiang-Tian MengHong-Yan Zhou
Jul 28, 2020·Cancers·Edwige VoissetPaulo de Sepulveda
Jul 13, 2021·Frontiers in Immunology·Lubica DraberovaPetr Draber

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Methods Mentioned

BETA
nucleotide exchange
electron microscopy
transfection
gene knock-out

Software Mentioned

NTAL
LAT

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