Transmembrane domain dependent inhibitory function of FcγRIIB

Protein & Cell
Junyi WangWanli Liu

Abstract

FcγRIIB, the only inhibitory IgG Fc receptor, functions to suppress the hyper-activation of immune cells. Numerous studies have illustrated its inhibitory function through the ITIM motif in the cytoplasmic tail of FcγRIIB. However, later studies revealed that in addition to the ITIM, the transmembrane (TM) domain of FcγRIIB is also indispensable for its inhibitory function. Indeed, recent epidemiological studies revealed that a non-synonymous single nucleotide polymorphism (rs1050501) within the TM domain of FcγRIIB, responsible for the I232T substitution, is associated with the susceptibility to systemic lupus erythematosus (SLE). In this review, we will summarize these epidemiological and functional studies of FcγRIIB-I232T in the past few years, and will further discuss the mechanisms accounting for the functional loss of FcγRIIB-I232T. Our review will help the reader gain a deeper understanding of the importance of the TM domain in mediating the inhibitory function of FcγRIIB and may provide insights to a new therapeutic target for the associated diseases.

References

Jan 1, 1991·Annual Review of Immunology·J V Ravetch, J P Kinet
Aug 1, 1989·European Journal of Immunology·S AmigorenaJ L Teillaud
Jan 1, 1997·Annual Review of Immunology·M Daëron
Oct 18, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·D C FongJ C Cambier
Oct 29, 2000·Biophysical Journal·J A BallesterosL Pardo
Sep 22, 2001·The Journal of Biological Chemistry·Y MimuraR Jefferis
Jun 22, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hajime KonoZen-ichiro Honda
Jan 8, 2003·The Journal of Cell Biology·Natsuko TanimuraAtsushi Kosugi
Apr 17, 2007·Proceedings of the National Academy of Sciences of the United States of America·Menna R ClatworthyKenneth G C Smith
Dec 8, 2007·Nature Reviews. Immunology·Falk Nimmerjahn, Jeffrey V Ravetch
Mar 6, 2009·Proceedings of the National Academy of Sciences of the United States of America·Björn TackenbergJan D Lünemann
Nov 17, 2009·Immunological Reviews·Ulrich BlankRenato C Monteiro
Jan 20, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Wanli LiuSusan K Pierce
Feb 12, 2010·Annals of the New York Academy of Sciences·Heather A NiedererKenneth G C Smith
Apr 14, 2010·Proceedings of the National Academy of Sciences of the United States of America·Lisa C WillcocksKenneth G C Smith
Apr 24, 2010·Nature Reviews. Immunology·Kenneth G C Smith, Menna R Clatworthy
May 29, 2010·Human Molecular Genetics·Heather A NiedererKenneth G C Smith
Mar 7, 2012·Expert Review of Clinical Immunology·Birgit LehmannFalk Nimmerjahn
Nov 29, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Gabriel R Starbeck-MillerJohn T Harty
Dec 20, 2013·Science Translational Medicine·Xinrui LiJeffrey C Edberg
May 3, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Liling XuWanli Liu
Jul 22, 2014·Nature Immunology·Andrew PinceticJeffrey V Ravetch
Jan 7, 2015·Proceedings of the National Academy of Sciences of the United States of America·Jinghua LuPeter D Sun

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Citations

Jul 2, 2020·Viruses·Chelsea T Barrett, Rebecca Ellis Dutch
Jan 11, 2020·Frontiers in Immunology·Bin SuChristiane Moog
Aug 30, 2020·Journal of Translational Medicine·Andrea Saul CostaJanardan P Pandey
Apr 4, 2019·Frontiers in Immunology·Jessica C AnaniaP Mark Hogarth

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Methods Mentioned

BETA
fluorescence

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