PMID: 9436632Jan 22, 1998Paper

Transmembrane redox signaling activates NF-kappaB in macrophages

Free Radical Biology & Medicine
N KaulH J Forman

Abstract

In macrophages, NF-kappaB can be activated by H2O2 generated by the respiratory burst or added exogenously. The mechanism of H2O2 signaling may involve changes in the cellular redox state or a redox reaction at the plasma membrane; however, the site of H2O2 action cannot be readily ascertained because of its membrane permeability. Ferricyanide, a nonpermeable redox active anion, activated NF-kappaB in the macrophage cell line, J774A.1. In contrast with exogenous H2O2, activation by ferricyanide did not correlate with net oxidation of NAD(P)H or glutathione, suggesting that a transplasma membrane redox reaction itself was the first signaling process in NF-kappaB activation.

References

Jan 1, 1992·Free Radical Research Communications·R SchreckP A Baeuerle
Oct 1, 1991·Journal of Bioenergetics and Biomembranes·F L CraneH Löw
Dec 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·F J StaalL A Herzenberg
Apr 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·L OsbornG J Nabel
Sep 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·R Gopalakrishna, W B Anderson
Oct 28, 1988·Science·P A Baeuerle, D Baltimore
Aug 1, 1985·Biochimica Et Biophysica Acta·F L CraneH Löw
Nov 6, 1984·Biochimica Et Biophysica Acta·P M McLoughlinF L Crane
Dec 14, 1984·Biochemical and Biophysical Research Communications·I L SunC Grebing
Dec 1, 1984·Journal of Bioenergetics and Biomembranes·I L SunH Löw
Dec 1, 1982·Journal of Bioenergetics and Biomembranes·F L CraneH Löw
Jun 15, 1982·The Biochemical Journal·M G ClarkF L Crane
Nov 22, 1994·Proceedings of the National Academy of Sciences of the United States of America·M T AndersonL A Herzenberg
May 16, 1995·Biochemical and Biophysical Research Communications·Y J SuzukiL Packer
Feb 1, 1995·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·S MihmW Dröge
Apr 1, 1993·AIDS Research and Human Retroviruses·F J StaalL A Herzenberg
Jan 1, 1996·Free Radical Biology & Medicine·H P Monteiro, A Stern
Jan 1, 1996·Free Radical Biology & Medicine·N Kaul, H J Forman

❮ Previous
Next ❯

Citations

Jul 2, 2003·Neurotoxicity Research·B H Juurlink
Aug 26, 2009·Archives of Dermatological Research·Cinzia CalcabriniMarina Dachà
Jun 20, 2002·Journal of Immunological Methods·James F CurtinThomas G Cotter
Mar 26, 2003·Free Radical Biology & Medicine·Said H AudiMarilyn P Merker
Jul 14, 2001·Colloids and Surfaces. B, Biointerfaces·H NygrenN Yahyapour
Aug 24, 1999·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·J S LeeA D Cooper
Mar 7, 2001·Antioxidants & Redox Signaling·J M Villalba, P Navas
Feb 28, 2002·American Journal of Respiratory Cell and Molecular Biology·Youssef OuadrhiriYves Sibille
Dec 13, 2006·American Journal of Respiratory Cell and Molecular Biology·Honglei LiuHenry Jay Forman
Dec 20, 2013·International Journal of Molecular Sciences·Jie LiHossein A Ghanbari
Nov 16, 2004·Mechanisms of Ageing and Development·Robert A Clark, Anthony J Valente
Apr 9, 2001·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·S E HoB H Lau
Aug 26, 1998·Chemico-biological Interactions·C Giulivi, E Cadenas
Jul 26, 2006·Free Radical Biology & Medicine·Derick HanNeil Kaplowitz
Oct 4, 2006·Free Radical Research·Honglei LiuHenry Jay Forman
Mar 1, 2000·Multiple Sclerosis : Clinical and Laboratory Research·B L BartnikR M Devon
Apr 27, 2004·Immunopharmacology and Immunotoxicology·Berislav BosnjakMarija Poljak-Blazi
Nov 11, 1999·Oncogene·F Mercurio, A M Manning
Aug 3, 2007·American Journal of Physiology. Renal Physiology·Hitesh PatniPravin C Singhal
Nov 13, 1998·Current Opinion in Lipidology·B L Thurberg, T Collins
May 15, 2001·American Journal of Physiology. Lung Cellular and Molecular Physiology·S H AudiC A Dawson
Feb 8, 2002·World Journal of Gastroenterology : WJG·Jian-Wei ZhuDong-Hua Li
Dec 14, 2001·American Journal of Physiology. Lung Cellular and Molecular Physiology·Marilyn P MerkerChristopher A Dawson
Jan 25, 2000·American Journal of Physiology. Heart and Circulatory Physiology·S H AudiC A Dawson

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.