Transmembrane semaphorins, forward and reverse signaling: have a look both ways

Cellular and Molecular Life Sciences : CMLS
Chiara Battistini, Luca Tamagnone

Abstract

Semaphorins are signaling molecules playing pivotal roles not only as axon guidance cues, but are also involved in the regulation of a range of biological processes, such as immune response, angiogenesis and invasive tumor growth. The main functional receptors for semaphorins are plexins, which are large single-pass transmembrane molecules. Semaphorin signaling through plexins-the "classical" forward signaling-affects cytoskeletal remodeling and integrin-dependent adhesion, consequently influencing cell migration. Intriguingly, semaphorins and plexins can interact not only in trans, but also in cis, leading to differentiated and highly regulated signaling outputs. Moreover, transmembrane semaphorins can also mediate a so-called "reverse" signaling, by acting not as ligands but rather as receptors, and initiate a signaling cascade through their own cytoplasmic domains. Semaphorin reverse signaling has been clearly demonstrated in fruit fly Sema1a, which is required to control motor axon defasciculation and target recognition during neuromuscular development. Sema1a invertebrate semaphorin is most similar to vertebrate class-6 semaphorins, and examples of semaphorin reverse signaling in mammalians have been described for these fa...Continue Reading

References

Sep 20, 1997·The Journal of Biological Chemistry·A ElhabaziG Bismuth
Jan 1, 1997·Molecular and Cellular Neurosciences·F EckhardtM C Fishman
May 13, 1999·The Journal of Biological Chemistry·L H WangS M Strittmatter
Jan 13, 2001·The Journal of Biological Chemistry·S InagakiT Furuyama
Aug 3, 2001·Journal of Neurochemistry·W SchultzeK S Erdmann
Oct 11, 2002·Nature·Atsushi KumanogohHitoshi Kikutani
Nov 19, 2002·Nature Neuroscience·Tanja A GodenschwegeRodney K Murphey
Feb 4, 2003·Nature Reviews. Immunology·Hitoshi Kikutani, Atsushi Kumanogoh
May 28, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jeffrey L GoldbergBen A Barres
Nov 16, 2004·Nature Cell Biology·Toshihiko ToyofukuHitoshi Kikutani
Dec 8, 2004·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Alice Davy, Philippe Soriano
Jan 6, 2005·Blood·Paolo ConrottoSilvia Giordano
Mar 5, 2005·International Immunology·Isabelle Chabbert-de PonnatLaurence Boumsell
Apr 9, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Fumikazu SutoHajime Fujisawa
Apr 14, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Patrick CaffertyYong Rao
May 23, 2006·Nature Cell Biology·Noriko TakegaharaHitoshi Kikutani
Feb 24, 2007·The EMBO Journal·Toshihiko ToyofukuMasatsugu Hori
Nov 21, 2007·The Journal of Biological Chemistry·Jakub M SwierczStefan Offermanns
Dec 20, 2007·Neural Development·Olivier MautiEsther T Stoeckli
Jul 16, 2008·Developmental Biology·Toshihiko ToyofukuHitoshi Kikutani
Dec 6, 2008·Genes & Development·Simona ParrinelloAlison C Lloyd
Dec 11, 2008·Journal of Clinical Immunology·Masayuki MizuiHitoshi Kikutani
Jun 13, 2009·World Journal of Gastroenterology : WJG·Guo-Qing PanJi-Fang Wen
Jan 15, 2010·International Journal of Cancer. Journal International Du Cancer·Anguraj SadanandamRakesh K Singh
Feb 18, 2010·Genes & Development·Homaira NawabiValérie Castellani
May 21, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Hiroshi TawarayamaHajime Fujisawa
Sep 10, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Li YuYong Rao

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Citations

Dec 3, 2016·Cell Adhesion & Migration·Lionel A T MeyerDominique Bagnard
Dec 23, 2016·The Journal of Cell Biology·Tianliang SunThomas Worzfeld
Apr 8, 2017·Molecular and Cellular Neurosciences·Gianfranco Gennarini, Andrew Furley
Jun 24, 2017·Medicinal Research Reviews·Roberto RoncaSandra Liekens
Jul 13, 2017·International Journal of Molecular Sciences·Vivian AdamskiKirsten Hattermann
Apr 4, 2020·BMC Medical Genomics·Xiaoli ZhangLang Li
Jan 20, 2019·International Journal of Molecular Sciences·Giulia Franzolin, Luca Tamagnone
Oct 17, 2019·Cancer Research·Luca Tamagnone, Giulia Franzolin
Sep 10, 2020·Cytokine & Growth Factor Reviews·Damon Fard, Luca Tamagnone
Feb 28, 2021·Nature Communications·Chen JiangThomas Worzfeld
Mar 2, 2021·Frontiers in Endocrinology·Celia G BarredoFrancisco A Martin
May 29, 2021·Frontiers in Synaptic Neuroscience·Daniela CarulliJoost Verhaagen
Aug 20, 2021·Frontiers in Cell and Developmental Biology·Anthony J Hayes, James Melrose

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