Transmissibility of tuberculosis among school contacts: an outbreak investigation in a boarding middle school, China

Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases
Mai-Juan MaWu-Chun Cao

Abstract

Tuberculosis (TB) outbreak occurred in a boarding middle school of China. We explored its probable sources and quantified the transmissibility and pathogenicity of TB. Clinical evaluation, tuberculin skin testing and chest radiography were conducted to identify TB cases. Mycobacterium tuberculosis isolates underwent genotyping analysis to identify the outbreak source. A chain-binomial transmission model was used to evaluate transmissibility and pathogenicity of TB. A total of 46 active cases were ascertained among 258 students and 15 teachers/staff, an attack rate of 16.8%. Genetic analyses revealed two groups of M. tuberculosis cocirculating during the outbreak and possible importation from local communities. Secondary attack rates among students were 4.1% (2.9%, 5.3%) within grade and 7.9% (4.9%, 11%) within class. An active TB case was estimated to infect 8.4 (7.2, 9.6) susceptible people on average. The smear-positive cases were 28 (8, 101) times as infective as smear-negative cases. Previous BCG vaccination could reduce the probability of developing symptoms after infection by 70% (1.4%, 91%). The integration of clinical evaluation, genetic sequencing, and statistical modeling greatly enhanced our understanding of TB trans...Continue Reading

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Citations

Mar 1, 2018·Epidemiology and Infection·Xiaoguang WuMengqiu Gao
Nov 28, 2019·Archives of Disease in Childhood·Ruling YangXiuhua Guo
May 7, 2019·Frontiers in Public Health·Marieke J van der Werf, Csaba Ködmön
Nov 14, 2019·International Journal of Environmental Research and Public Health·Shu YangXiaoling Zhang
Dec 14, 2018·International Journal of Environmental Research and Public Health·Dongxiang PanVirasakdi Chongsuvivatwong
Oct 30, 2021·Frontiers in Public Health·Hui LiGuolong Zhang

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