Transmissible cancer in Tasmanian devils: localized lineage replacement and host population response

Proceedings. Biological Sciences
Rodrigo HamedeMenna E Jones

Abstract

Tasmanian devil facial tumour disease (DFTD) is a clonally transmissible cancer threatening the Tasmanian devil (Sarcophilus harrisii) with extinction. Live cancer cells are the infectious agent, transmitted to new hosts when individuals bite each other. Over the 18 years since DFTD was first observed, distinct genetic and karyotypic sublineages have evolved. In this longitudinal study, we investigate the associations between tumour karyotype, epidemic patterns and host demographic response to the disease. Reduced host population effects and low DFTD infection rates were associated with high prevalence of tetraploid tumours. Subsequent replacement by a diploid variant of DFTD coincided with a rapid increase in disease prevalence, population decline and reduced mean age of the population. Our results suggest a role for tumour genetics in DFTD transmission dynamics and epidemic outcome. Future research, for this and other highly pathogenic emerging infectious diseases, should focus on understanding the evolution of host and pathogen genotypes, their effects on susceptibility and tolerance to infection, and their implications for designing novel genetic management strategies. This study provides evidence for a rapid localized line...Continue Reading

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Citations

Feb 16, 2018·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Tracey RussellBeata Ujvari
Aug 3, 2018·PLoS Pathogens·Andrew StorferMenna E Jones
Aug 31, 2016·Nature Communications·Brendan EpsteinAndrew Storfer
Nov 23, 2018·Proceedings. Biological Sciences·Manuel Ruiz-AravenaRodrigo K Hamede
Sep 27, 2018·Integrative and Comparative Biology·Gregory M WoodsSilvana S Bettiol
Jan 24, 2020·Expert Review of Vaccines·Andrew S FliesRuth J Pye
Nov 16, 2019·Parasitology·Frédéric ThomasBeata Ujvari
Aug 10, 2018·The Journal of Applied Ecology·Billie T LazenbyDavid Pemberton
May 24, 2020·Evolution; International Journal of Organic Evolution·Alexandra K FraikAndrew Storfer
Aug 22, 2020·Evolutionary Applications·Rodrigo HamedeFrédéric Thomas
Sep 26, 2019·Conservation Genetics·Paul A HohenloheAndrew Storfer
Jul 26, 2017·Scientific Reports·Rodrigo K HamedeMenna E Jones
Dec 12, 2020·Science·Austin H PattonAndrew Storfer

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