Transmission and fluorescence angular domain optical projection tomography of turbid media

Applied Optics
F VasefiJeffery J L Carson

Abstract

When imaging through turbid media, objects are often blurred by scattered light. An optical collimator (i.e., an angular filter array) improves images by accepting only photons propagating within a narrow solid angle about the direction of the incident light. These photons are expected to participate in a limited number of small-angle scattering events, maintaining their original propagation direction and, finally, contributing to the development of a faithful image of an object within a turbid medium. The collimation method, also referred to as angular domain imaging (ADI), applies to a see-through configuration where the incident collimated light beam can be aligned with the collimator in a transillumination mode of operation. In this paper, we present angular domain optical projection tomography (ADOPT), a method that can extract depth information of optical contrast in turbid media with high longitudinal resolution based on ADI technology. The resolution of the ADI system has been tested over various depths in a 5 cm optical cuvette using a resolution target suspended in a homogeneous turbid medium. The ADOPT system reconstructed images from a series of angular domain projections collected at angular intervals. The system w...Continue Reading

References

Aug 12, 2000·Journal of Biomedical Optics·K ChenM S Feld
May 30, 2003·Medical Physics·Edward E GravesVasilis Ntziachristos
Jul 23, 2003·Physics in Medicine and Biology·Anuradha GodavartyEva M Sevick-Muraca
Mar 15, 2005·Optics Letters·Gordon M TurnerVasilis Ntziachristos
Mar 15, 2005·Nature Biotechnology·Vasilis NtziachristosRalph Weissleder
Apr 21, 2007·Nature Protocols·Hao F ZhangLihong V Wang
Mar 4, 2008·Optics Letters·Anand T N KumarDavid A Boas
Dec 24, 2008·Optics Express·Fartash VasefiJeffrey J L Carson
Jun 15, 1993·Optics Letters·M R HeeE A Swanson
Jan 15, 1996·Optics Letters·M A O'LearyA G Yodh
Nov 1, 1991·Applied Optics·H J van StaverenM J van Gemert

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Citations

Sep 8, 2011·Journal of Biomedical Optics·Fartash VasefiJeffrey Carson
Sep 26, 2012·IEEE Journal of Biomedical and Health Informatics·Di DongJ Ripoll
Mar 1, 2012·IEEE Transactions on Medical Imaging·Shouping ZhuJorge Ripoll

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