Nov 2, 2018

Acquisition, transmission and strain diversity of human gut-colonizing crAss-like phages

BioRxiv : the Preprint Server for Biology
Fiona B TamburiniAmi S Bhatt

Abstract

CrAss-like phages are double-stranded DNA viruses that are prevalent in human gut microbiomes. Here, we analyze gut metagenomic data from mother-infant pairs and patients undergoing fecal microbiota transplantation to evaluate the patterns of acquisition, transmission and strain diversity of crAss-like phages. We find that crAss-like phages are rarely detected at birth but are increasingly prevalent in the infant microbiome after one month of life. We observe nearly identical genomes in 50% of cases where the same crAss-like clade is detected in both the mother and the infant, suggesting vertical transmission. In cases of putative transmission of prototypical crAssphage (p-crAssphage), we find that a subset of strains present in the mother are detected in the infant, and that strain diversity in infants increases with time. Strain diversity in the p-crAssphage population in mothers is generally low, with a median of 50 variable sites in the 97kb genome. Putative tail fiber proteins are enriched for nonsynonymous strain variation compared to other genes, suggesting a potential evolutionary benefit to maintaining strain diversity in specific genes. Finally, we show that p-crAssphage can be acquired through fecal microbiota transp...Continue Reading

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Mentioned in this Paper

Study
Patterns
Entire Gastrointestinal Tract
Bacteriophages
Gastrointestinal Neoplasms
Microbiome
Disease Transmission
Microbiota (Procedure)
Fecal Microbiota Transplantation
Feces

About this Paper

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