Transmission disequilibrium analysis of HLA class II DRB1, DQA1, DQB1 and DPB1 polymorphisms in schizophrenia using family trios from a Han Chinese population

Schizophrenia Research
T LiD A Collier

Abstract

Our goal was to evaluate the role of HLA in the risk of developing schizophrenia, in a Han Chinese population. In several Japanese studies, there is evidence of association with DR1 and schizophrenia. A variety of other associations have been reported in other populations, including negative associations with DQbeta(*)0602 and positive associations with DR1(*)0101. Using sequence specific oligonucleotides, we genotyped four HLA markers (DRB1, DQA1, DQB1 and DPB1) in 165 family trios, consisting of Han Chinese schizophrenic subjects and their parents. Individual markers were analysed for transmission distortion in the trios using the transmission disequilibrium test. Multiple haplotype transmission was performed using the program TRANSMIT v2.5. The four markers were in strong linkage disequilibrium with each other (P value from 0.002 to 0). There was no evidence of overall transmission disequilibrium for each of the four loci. For DRB1, we did not find transmission distortion for the DRB1(*)04 and DRB1(*)08 alleles, as reported previously, but the DRB1(*)03 allele was preferentially not transmitted (P=0.009), and the DRB1(*)13 allele was preferentially transmitted from parents to schizophrenic offspring (P=0.041). Using haplotyp...Continue Reading

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Citations

Jul 3, 2009·Nature·Hreinn StefanssonDavid A Collier
Jun 23, 2005·Cognitive and Behavioral Neurology : Official Journal of the Society for Behavioral and Cognitive Neurology·Mark WalterfangDennis Velakoulis
Sep 12, 2008·Biological Reviews of the Cambridge Philosophical Society·Bernard Crespi
Jun 9, 2011·Genes, Brain, and Behavior·B J Crespi, D L Thiselton
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Jul 31, 2013·Biological Psychiatry·Szatmár Horváth, Károly Mirnics
Jul 21, 2012·Progress in Neuro-psychopharmacology & Biological Psychiatry·Monojit DebnathGanesan Venkatasubramanian
Oct 12, 2012·Asian Journal of Psychiatry·Bisu SinghTapas Kumar Chaudhuri
Sep 13, 2008·Progress in Neuro-psychopharmacology & Biological Psychiatry·Yu-Lin ChaoChia-Hsiang Chen
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Apr 5, 2011·Psychiatry Research·Bisu SinghTapas Kumar Chaudhuri

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