Transmission dynamics of gram-negative bacterial pathogens in the anesthesia work area

Anesthesia and Analgesia
Randy W LoftusMark P Yeager

Abstract

Gram-negative organisms are a major health care concern with increasing prevalence of infection and community spread. Our primary aim was to characterize the transmission dynamics of frequently encountered gram-negative bacteria in the anesthesia work area environment (AWE). Our secondary aim was to examine links between these transmission events and 30-day postoperative health care-associated infections (HCAIs). Gram-negative isolates obtained from the AWE (patient nasopharynx and axilla, anesthesia provider hands, and the adjustable pressure-limiting valve and agent dial of the anesthesia machine) at 3 major academic medical centers were identified as possible intraoperative bacterial transmission events by class of pathogen, temporal association, and phenotypic analysis (analytical profile indexing). The top 5 frequently encountered genera were subjected to antibiotic disk diffusion sensitivity to identify epidemiologically related transmission events. Complete multivariable logistic regression analysis and binomial tests of proportion were then used to examine the relative contributions of reservoirs of origin and within- and between-case modes of transmission, respectively, to epidemiologically related transmission events....Continue Reading

Associated Clinical Trials

References

May 1, 1989·Journal of Clinical Microbiology·I Brook
Feb 1, 1994·Journal of Clinical Microbiology·F C TenoverR Hollis
Apr 1, 1996·Chest·S Crouch BrewerK V Leeper
Apr 1, 1997·Clinical Microbiology Reviews·W E Sanders, C C Sanders
Apr 1, 1997·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·D W BeezholdR A Weinstein
Nov 1, 2003·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Leonard A MermelStephen Parenteau
Mar 29, 2005·Antimicrobial Agents and Chemotherapy·Scott T MicekMarin H Kollef
Jan 9, 2008·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Mary K HaydenRobert A Weinstein
Mar 19, 2008·Clinical Orthopaedics and Related Research·Jason H CalhounM M Manring
Oct 14, 2008·Expert Review of Anti-infective Therapy·Jesús Rodríguez-Baño, Alvaro Pascual
Nov 22, 2008·The Journal of Hospital Infection·C D Owens, K Stoessel
Dec 5, 2008·FEMS Microbiology Reviews·Barry R Bochner
Dec 17, 2009·American Journal of Infection Control·Jonathan R EdwardsTeresa C Horan
Oct 12, 2010·Indian Journal of Pediatrics·Eric J McGrath, Basim I Asmar
Nov 16, 2010·International Journal of Antimicrobial Agents·Zubair A QureshiYohei Doi
Mar 15, 2011·Diagnostic Microbiology and Infectious Disease·Francesco LuzzaroGiovanni Gesu
Apr 5, 2011·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·M R LeeP R Hsueh
Apr 3, 2012·Anesthesia and Analgesia·Randy W LoftusMark P Yeager
Jan 29, 2013·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·E MontassierM F de La Cochetière

❮ Previous
Next ❯

Citations

Mar 21, 2017·Current Opinion in Anaesthesiology·Sharon Einav, Yonit Wiener-Well
Apr 23, 2017·American Journal of Infection Control·Matthew NottinghamGonzalo Bearman
Dec 12, 2018·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·L Silvia Munoz-PriceDavid J Birnbach
Mar 20, 2015·Anesthesia and Analgesia·Steven L Shafer
Mar 20, 2015·Anesthesia and Analgesia·L Silvia Munoz-Price, Robert A Weinstein
Jul 28, 2015·Anesthesia and Analgesia·David J BirnbachL Silvia Munoz-Price
Jan 15, 2016·Current Opinion in Anaesthesiology·Randy W Loftus
Feb 5, 2016·Anesthesiology·Warren S Sandberg, Thomas R Talbot
Apr 7, 2018·The Canadian Journal of Infectious Diseases & Medical Microbiology = Journal Canadien Des Maladies Infectieuses Et De La Microbiologie Médicale·Chuck J BiddleBrad Verhulst
May 21, 2021·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Debby Ben-DavidMitchell J Schwaber

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.