Transmission electron and high-voltage electron microscopy of osteocyte cellular processes extending to the dental implant surface

Journal of Biomedical Materials Research
D E SteflikP Brewer


Examination of the morphology of osteocytes within the bone supporting endosteal dental implants was performed using conventional transmission and high-voltage transmission electron microscopy (HVEM). The in vivo dog model used 72 implants inserted into the premolar region of 18 experimental animals. Forty-eight implants in 12 dogs were used as anterior abutments for fixed bridges for periods up to 12 months. The mineralized matrix of the supporting bone was either directly apposed to the implant surface or was separated from the implant by a narrow region of unmineralized matrix. Osteocytes were routinely observed to be closely associated with the bone-implant interface, as well as at a distance from the implant. Osteocytes were found to extend cellular processes directly to the implant surface through canaliculi. The osteocyte processes contained microfilaments. The three-dimensional capabilities of HVEM elucidated the nature of these cell processes at the point of exit from the osteocyte, as the processes extended through the mineralized matrix, and as the processes terminated at the implant interface. This report suggests that avenues of communication may exist between the implant and the osseous cells, providing intriguing...Continue Reading


Sep 1, 1992·The Journal of Prosthetic Dentistry·G R ParrA L Sisk
Jul 1, 1992·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·A L SiskP J Hanes
Apr 1, 1990·Journal of Biomedical Materials Research·C A van BlitterswijkK De Groot
Jul 1, 1990·Journal of Biomedical Materials Research·G L De LangeF L De Wijs
Dec 1, 1988·The Journal of Prosthetic Dentistry·L B LumT A Curtis
Mar 1, 1987·Oral Microbiology and Immunology·J CarlssonS K Lundmark
Mar 1, 1987·Journal of Biomedical Materials Research·J C KellerJ R Natiella
Dec 1, 1981·International Journal of Oral Surgery·R AdellP I Brånemark
Feb 1, 1983·Acta Orthopaedica Scandinavica·L LinderI Lundström


Mar 10, 1998·Journal of Biomedical Materials Research·D E SteflikD J Berkery
May 1, 1996·Journal of Dentistry·D BrownD Wood
Feb 1, 1996·Journal of Oral Rehabilitation·J C Wataha
Feb 26, 2005·Clinical and Experimental Pharmacology & Physiology·Iven Klineberg
May 25, 1999·Periodontology 2000·S G Steinemann
Apr 18, 2012·Journal of Oral Rehabilitation·I J KlinebergG M Murray
Oct 8, 2014·Journal of Orthopaedic Surgery and Research·Arihiko KanajiKotaro Sena
Nov 24, 1998·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·M M KlingerJ E Lemons
Mar 30, 2001·Advances in Dental Research·D E SteflikG R Parr
Dec 24, 2018·Journal of Biomedical Materials Research. Part a·Yoko TakemuraKiyoshi Koyano
May 28, 2004·The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology·Li-Dan YouMitchell B Schaffler

Related Concepts

Canis familiaris
Electron Microscopy
Surface Properties
Dental Prostheses, Surgical

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Lipidomics & Rhinovirus Infection

Lipidomics can be used to examine the lipid species involved with pathogenic conditions, such as viral associated inflammation. Discovered the latest research on Lipidomics & Rhinovirus Infection.

Spatio-Temporal Regulation of DNA Repair

DNA repair is a complex process regulated by several different classes of enzymes, including ligases, endonucleases, and polymerases. This feed focuses on the spatial and temporal regulation that accompanies DNA damage signaling and repair enzymes and processes.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Torsion Dystonia

Torsion dystonia is a movement disorder characterized by loss of control of voluntary movements appearing as sustained muscle contractions and/or abnormal postures. Here is the latest research.

Archaeal RNA Polymerase

Archaeal RNA polymerases are most similar to eukaryotic RNA polymerase II but require the support of only two archaeal general transcription factors, TBP (TATA-box binding protein) and TFB (archaeal homologue of the eukaryotic general transcription factor TFIIB) to initiate basal transcription. Here is the latest research on archaeal RNA polymerases.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Central Pontine Myelinolysis

Central Pontine Myelinolysis is a neurologic disorder caused most frequently by rapid correction of hyponatremia and is characterized by demyelination that affects the central portion of the base of the pons. Here is the latest research on this disease.