Transmission electron microscopic observations on ultrastructural alterations in Schistosoma mansoni adult worms recovered from C57BL/6 mice treated with radiation-attenuated vaccine and/or praziquantel in addition to passive immunization with normal and vaccinated rabbit sera against infection

Parasitology Research
Eman A El-ShabasyAllal Ouhtit

Abstract

Although the current treatment of schistosomiasis relies largely on praziquantel (PZQ), it has not been successful in significantly reducing the overall rate of disease cases, one of the suggested reasons being the inevitable resistance to PZQ. Previous studies showed that radiation-attenuated vaccine provides protection against Schistosoma mansoni in a host of various species. In the present study, we evaluated the effect of various vaccination strategies in C57BL/6 mice, including single or multiple vaccination strategy, subcurative dose (20 mg/kg) of PZQ, and a combination of single vaccination with subcurative dose of PZQ. Treatment either with subcurative dose of PZQ or with a single vaccination of attenuated cercariae (500 per mouse), caused significant reduction in total worm burden, hepatic, and intestinal ova counts of 43.03, 73.2, and 59.5 and 37.97, 52.02, and 26.3%, respectively. Furthermore, tegumental changes were observed. In multiple vaccinated group, there was an extensive lysis in tegumental layers. High deformations in gastrodermis, testis cells, vitelline cells, and oocytes were recorded. Also, this study is to explore the role of humoral immunity using highly resistant rabbits that had been exposed to three...Continue Reading

References

Jan 1, 1977·Advances in Parasitology·D A Erasmus
Jan 1, 1989·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·P F Basch, L E Clemens
Oct 6, 1969·Annals of the New York Academy of Sciences·A W Senft
Mar 1, 1984·Journal of Helminthology·J Clarkson, D A Erasmus
Feb 1, 1983·Experimental Parasitology·D A Dean
Aug 1, 1984·Parasitology·B LeitchN W Runham
Dec 1, 1984·Experimental Parasitology·B Leitch, A J Probert
Feb 1, 1981·Parasitology·O A Otubanjo
Apr 16, 1996·Proceedings of the National Academy of Sciences of the United States of America·P J Skelly, C B Shoemaker
Dec 11, 1999·Molecular and Biochemical Parasitology·E L RacoosinE J Pearce
Dec 22, 1999·Microbes and Infection·R A Wilson, P S Coulson
Sep 21, 2000·Acta Tropica·L ChitsuloL Savioli
Aug 23, 2001·Veterinary Parasitology·N C Sangster
May 22, 2002·Acta Tropica·Robert BergquistRichard Olds
Dec 12, 2002·Transactions of the Royal Society of Tropical Medicine and Hygiene·Michael J DoenhoffDonato Cioli
Nov 26, 2003·International Journal for Parasitology·Geoffrey N GobertMalcolm K Jones
Dec 4, 2003·Expert Opinion on Biological Therapy·Paul Hagan, Osama Sharaf
Mar 5, 2004·Expert Opinion on Pharmacotherapy·Jürg Utzinger, Jennifer Keiser
Jun 1, 2005·Parasitology International·Wannee JiraungkoorskulNiwat Kangwanrangsan
Jun 1, 2006·Advances in Parasitology·Alan FenwickVaughan Southgate
Sep 26, 2006·Lancet·Bruno GryseelsLuc Kestens
Oct 17, 2006·Parasitology Today·N R Bergquist, D G Colley
Jul 27, 2007·Current Opinion in Chemical Biology·Conor R Caffrey

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Citations

Oct 8, 2016·Parasites & Vectors·Biniam Mathewos TebejeDonald P McManus
Mar 23, 2017·Memórias do Instituto Oswaldo Cruz·Reem Osama A Kamel, Fatma El-Zahraa Anwar Bayaumy
Oct 28, 2019·Parasitology Research·Asmaa R EllakanyAmira E Abdel Ghaffar
Oct 14, 2021·PLoS Neglected Tropical Diseases·Shereen F MossallamRadwa G Diab

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