Transmission in heteronymous spinal pathways is modified after stroke and related to motor incoordination.

PloS One
Joseph-Omer DyerRobert Forget

Abstract

Changes in reflex spinal pathways after stroke have been shown to affect motor activity in agonist and antagonist muscles acting at the same joint. However, only a few studies have evaluated the heteronymous reflex pathways modulating motoneuronal activity at different joints. This study investigates whether there are changes in the spinal facilitatory and inhibitory pathways linking knee to ankle extensors and if such changes may be related to motor deficits after stroke. The early facilitation and later inhibition of soleus H reflex evoked by the stimulation of femoral nerve at 2 times the motor threshold of the quadriceps were assessed in 15 healthy participants and on the paretic and the non-paretic sides of 15 stroke participants. The relationships between this reflex modulation and the levels of motor recovery, coordination and spasticity were then studied. Results show a significant (Mann-Whitney U; P<0.05) increase in both the peak amplitude (mean+/-SEM: 80+/-22% enhancement of the control H reflex) and duration (4.2+/-0.5 ms) of the facilitation on the paretic side of the stroke individuals compared to their non-paretic side (36+/-6% and 2.9+/-0.4 ms) and to the values of the control subjects (33+/-4% and 2.8+/-0.4 ms,...Continue Reading

References

Apr 20, 1979·Brain Research·E Pierrot-DeseillignyC Morin
Jun 1, 1979·Brain : a Journal of Neurology·E Knutsson, C Richards
Jul 1, 1977·The Journal of Physiology·B Bussel, E Pierrot-Deseilligny
Feb 1, 1992·The Journal of Physiology·A Lev-Tov, M Pinco
May 1, 1989·The American Journal of Occupational Therapy : Official Publication of the American Occupational Therapy Association·D Bourbonnais, S Vanden Noven
Dec 1, 1988·Journal of Neurology, Neurosurgery, and Psychiatry·P J Delwaide, E Oliver
Aug 1, 1987·The Journal of Physiology·H HultbornE Pierrot-Deseilligny
Dec 1, 1974·Journal of Neurology, Neurosurgery, and Psychiatry·P AshbyE Lightfoot
Jun 1, 1980·Electroencephalography and Clinical Neurophysiology·B Piesiur-Strehlow, H M Meinck
Jan 1, 1981·Experimental Brain Research·H M Meinck, B Piesiur-Strehlow
Mar 1, 1982·Brain : a Journal of Neurology·R Katz, E Pierrot-Deseilligny
Jan 1, 1981·Experimental Brain Research·E Pierrot-DeseillignyN Tankov
Jan 1, 1981·Journal of Biomechanics·S R SimonE L Radin
Jan 1, 1995·Experimental Brain Research·M SchieppatiM Grasso
Sep 1, 1995·American Journal of Physical Medicine & Rehabilitation·M PanizzaJ Nilsson
Aug 1, 1995·Brain : a Journal of Neurology·J NielsenC Crone
Jan 1, 1994·Experimental Brain Research·S MeunierM Simonetta-Moreau
Jan 1, 1994·Acta Physiologica Scandinavica·D Mazevet, E Pierrot-Deseilligny
Oct 1, 1993·Acta Physiologica Scandinavica·R KatzA Rossi
Jan 1, 1993·Experimental Brain Research·S MeunierM Simonetta
Jul 1, 1993·Journal of Neurology, Neurosurgery, and Psychiatry·J H KoelmanB W Ongerboer de Visser
Jan 1, 1993·Stroke; a Journal of Cerebral Circulation·C GowlandN Plews
Sep 15, 1995·The Journal of Physiology·M Schieppati, A Nardone
Feb 1, 1996·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Y Okuma, R G Lee
Oct 6, 1997·Brain : a Journal of Neurology·J NetzV Hömberg

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Citations

Aug 3, 2011·Journal of Neuroengineering and Rehabilitation·Joseph-Omer DyerRobert Forget
Feb 10, 2011·Brain : a Journal of Neurology·Evelyne KloterVolker Dietz
Oct 17, 2013·Expert Review of Clinical Immunology·Yashwant Kumar, Alka Bhatia
Apr 1, 2014·Archives of Physical Medicine and Rehabilitation·Marina B PinheiroLuci F Teixeira-Salmela
Jan 10, 2012·Experimental Neurology·Michèle HubliVolker Dietz
Jul 12, 2013·Topics in Stroke Rehabilitation·Clinton J WutzkeMichael D Lewek
Nov 13, 2018·The Journal of Physiology·Sidney GrosprêtreAlain Martin
Mar 29, 2014·Journal of Neurophysiology·Derek G KamperKristen M Triandafilou
Mar 1, 2014·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Riccardo Mazzocchio, Matteo Caleo

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