Abstract
Borrelia miyamotoi sensu lato relapsing fever group spirochetes are emerging as causative agents of human illness (Borrelia miyamotoi disease) in the United States. Host-seeking Ixodes scapularis ticks are naturally infected with these spirochetes in the eastern United States and experimentally capable of transmitting B. miyamotoi. However, the duration of time required from tick attachment to spirochete transmission has yet to be determined. We therefore conducted a study to assess spirochete transmission by single transovarially infected I. scapularis nymphs to outbred white mice at three time points post-attachment (24, 48, and 72h) and for a complete feed (>72-96h). Based on detection of B. miyamotoi DNA from the blood of mice fed on by an infected nymph, the probability of spirochete transmission increased from 10% by 24h of attachment (evidence of infection in 3/30 mice) to 31% by 48h (11/35 mice), 63% by 72h (22/35 mice), and 73% for a complete feed (22/30 mice). We conclude that (i) single I. scapularis nymphs effectively transmit B. miyamotoi relapsing fever group spirochetes while feeding, (ii) transmission can occur within the first 24h of nymphal attachment, and (iii) the probability of transmission increases with t...Continue Reading
Citations
Mar 27, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Richard C FalcoGary P Wormser
Jan 25, 2018·Journal of Medical Entomology·Nicole E BreunerLars Eisen
Jan 25, 2018·Journal of Medical Entomology·Geoffrey E LynnRebecca J Eisen
Dec 21, 2017·Terapevticheskiĭ arkhiv·A E PlatonovV V Maleev
Jan 16, 2019·Infection and Immunity·Monica E EmbersJob E Lopez
Aug 31, 2018·Emerging Infectious Diseases·Jack D BissettJob E Lopez
May 9, 2019·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·Sally CutlerHervé Zeller
Nov 7, 2019·Journal of Medical Entomology·Michael L LevinAlyssa N Snellgrove
Apr 17, 2020·Healthcare·Melissa C FeslerRaphael B Stricker
Nov 16, 2019·Scientific Reports·Emma K HarrisRobert D Gilmore
Oct 13, 2020·PloS One·Aparna KrishnavajhalaJob E Lopez
Nov 17, 2020·Frontiers in Medicine·Shannon L DelaneyBrian A Fallon
Jan 9, 2021·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Paul M LantosLawrence S Zemel
Jan 23, 2021·Scientific Reports·Adam J ReplogleJeannine M Petersen
Mar 2, 2021·Frontiers in Immunology·Nathalie Boulanger, Stephen Wikel
Mar 9, 2019·Ticks and Tick-borne Diseases·Seungeun HanJean I Tsao
Apr 12, 2021·Wilderness & Environmental Medicine·David Della-GiustinaKatja Goldflam
Oct 10, 2020·Ticks and Tick-borne Diseases·Seungeun HanJean I Tsao