Transmission of cochlear distortion products as slow waves: a comparison of experimental and model data

The Journal of the Acoustical Society of America
Ales Vetesnik, Anthony Gummer

Abstract

There is a long-lasting question of how distortion products (DPs) arising from nonlinear amplification processes in the cochlea are transmitted from their generation sites to the stapes. Two hypotheses have been proposed: (1) the slow-wave hypothesis whereby transmission is via the transverse pressure difference across the cochlear partition and (2) the fast-wave hypothesis proposing transmission via longitudinal compression waves. Ren with co-workers have addressed this topic experimentally by measuring the spatial vibration pattern of the basilar membrane (BM) in response to two tones of frequency f(1) and f(2). They interpreted the observed negative phase slopes of the stationary BM vibrations at the cubic distortion frequency f(DP) = 2f(1) - f(2) as evidence for the fast-wave hypothesis. Here, using a physically based model, it is shown that their phase data is actually in accordance with the slow-wave hypothesis. The analysis is based on a frequency-domain formulation of the two-dimensional motion equation of a nonlinear hydrodynamic cochlea model. Application of the analysis to their experimental data suggests that the measurement sites of negative phase slope were located at or apical to the DP generation sites. Therefor...Continue Reading

References

May 1, 1978·The Journal of the Acoustical Society of America·M M Sondhi
Jan 1, 1976·Cold Spring Harbor Symposia on Quantitative Biology·G Zweig
Oct 22, 1992·Proceedings. Biological Sciences·A M BrownD M Williams
Jan 1, 1991·The Journal of the Acoustical Society of America·S Puria, J B Allen
Mar 1, 1991·The Journal of the Acoustical Society of America·C A Shera, G Zweig
Jun 1, 1990·The Journal of the Acoustical Society of America·D D Greenwood
May 1, 1989·Hearing Research·R B PatuzziB M Johnstone
Jan 11, 1985·Science·W E BrownellY de Ribaupierre
Aug 1, 1970·The Journal of the Acoustical Society of America·P Dallos
May 1, 1980·The Journal of the Acoustical Society of America·J J Zwislocki
Dec 1, 1980·The Journal of the Acoustical Society of America·J B Allen
Jun 1, 1993·The Journal of the Acoustical Society of America·F Mammano, R Nobili
Aug 5, 1993·Nature·F JaramilloA J Hudspeth
Aug 1, 1993·The Journal of the Acoustical Society of America·J B Allen, P F Fahey
Mar 19, 1996·Proceedings of the National Academy of Sciences of the United States of America·R S ChadwickK H Iwasa
Aug 6, 1996·Proceedings of the National Academy of Sciences of the United States of America·A W GummerH P Zenner
Apr 1, 1996·The Journal of the Acoustical Society of America·R Nobili, F Mammano
Feb 28, 1998·The Journal of the Acoustical Society of America·A N Lukashkin, I J Russell
Apr 29, 1998·Trends in Neurosciences·R NobiliJ Ashmore
Sep 24, 1998·The Journal of the Acoustical Society of America·C L TalmadgeP Piskorski
Feb 11, 1999·The Journal of the Acoustical Society of America·C A Shera, J J Guinan
Apr 14, 1999·Proceedings of the National Academy of Sciences of the United States of America·G FrankA W Gummer
Jun 28, 2001·Physiological Reviews·L Robles, M A Ruggero
Sep 27, 2002·British Medical Bulletin·David T Kemp
Dec 4, 2002·Proceedings of the National Academy of Sciences of the United States of America·Tianying Ren
Mar 27, 2003·The Journal of the Acoustical Society of America·Andrei N Lukashkin, Ian J Russell
May 27, 2003·The Journal of the Acoustical Society of America·Sunil Puria
Sep 1, 1958·The Annals of Otology, Rhinology, and Laryngology·H DAVIS
Sep 23, 2003·Current Opinion in Otolaryngology & Head and Neck Surgery·Brenda L Lonsbury-Martin, Glen K Martin
Dec 24, 2003·Journal of the Association for Research in Otolaryngology : JARO·Peter Dallos
Mar 23, 2004·Nature Neuroscience·Tianying Ren
Apr 7, 2004·Proceedings of the National Academy of Sciences of the United States of America·Hongxue CaiRichard S Chadwick
Jun 17, 2005·The Journal of the Acoustical Society of America·Wei Dong, Elizabeth S Olson
Aug 27, 2005·The Journal of the Acoustical Society of America·Christopher A SheraCarrick L Talmadge
Feb 8, 2006·Proceedings of the National Academy of Sciences of the United States of America·Manuela Nowotny, Anthony W Gummer
Aug 11, 2006·Journal of Neurophysiology·Tianying RenAlfred L Nuttall
Sep 30, 2006·Hearing Research·A Vetesník, R Nobili
Oct 27, 2006·ORL; Journal for Oto-rhino-laryngology and Its Related Specialties·Ales VetesnikAnthony Gummer
Feb 15, 2007·The Journal of the Acoustical Society of America·Egbert de BoerChristopher A Shera
Apr 6, 2007·The Journal of the Acoustical Society of America·Christopher A SheraJohn J Guinan
Oct 11, 2007·Proceedings of the National Academy of Sciences of the United States of America·Roozbeh GhaffariDennis M Freeman
Jan 8, 2008·The Journal of the Acoustical Society of America·W Dong, E S Olson
Feb 15, 2008·Proceedings of the National Academy of Sciences of the United States of America·Wenxuan HeTianying Ren

❮ Previous
Next ❯

Citations

Jul 19, 2013·The Journal of the Acoustical Society of America·Glen K MartinBrenda L Lonsbury-Martin
Apr 6, 2013·The Journal of the Acoustical Society of America·Christopher A Shera, Nigel P Cooper
Oct 19, 2013·Physiological Reviews·Paul AvanChristine Petit
Sep 2, 2019·The Journal of the Acoustical Society of America·Václav VencovskýAnthony W Gummer
Feb 8, 2018·Biophysical Journal·Thomas Bowling, Julien Meaud

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Journal of the Acoustical Society of America
Renata SistoChristopher A Shera
The Journal of the Acoustical Society of America
Yizeng Li, Karl Grosh
Proceedings of the National Academy of Sciences of the United States of America
Wenxuan HeTianying Ren
The Journal of the Acoustical Society of America
Egbert de Boer, Alfred L Nuttall
© 2021 Meta ULC. All rights reserved