Transmission of hepatitis B virus (HBV) genotypes among Japanese immigrants and natives in Bolivia

Virus Research
Anis KhanMasashi Mizokami

Abstract

Hepatitis B virus genotypes are associated with transmission pattern, virological and clinical features and outcome of the chronic infection course. HBV genotypes other than Genotype F (HBV/F) are considered a reflection of human migration into South America. A total of 487 individuals in Bolivia, including Japanese immigrants (n=287) and natives (n=200), were screened for HBV serological markers. Overall 22/487 (4.5%) of the subjects were positive for HBsAg, 217/487 (44.5%) for anti-HBc and 162/487 (33.3%) for anti-HBs. Genotypes were determinable in 22 cases by EIA, followed by sequencing and phylogenetic analysis in 17 cases. HBV genotype distribution in Japanese and Bolivians was HBV/F (4 and 8); HBV/C (5 and 3); and HBV/B (1 and 1), respectively. Phylogenetic analyses of nine complete and eight partial (HBsAg/pre-core/core region) genomes, revealed that HBV/F strains cluster with previously reported regional strains, whereas HBV/B and HBV/C strains belonged to Asian subgenotype B2 (Ba) and C2 (Ce), respectively. Japanese immigrants might have introduced HBV/B and HBV/C to natives in Bolivia, conversely, exposed to the indigenous HBV/F. This report provides evidence of an inter-communities transmission of HBV revealed by it...Continue Reading

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Citations

Apr 17, 2009·Journal of Gastroenterology·Cintia Mendes ClementeIsabel Maria Vicente Guedes de Carvalho Mello
Oct 28, 2008·Archives of Virology·Mauricio VenegasJavier Brahm
Jul 22, 2010·Journal of Medical Virology·Sonia RomanArturo Panduro
Feb 17, 2010·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Fuat KurbanovMasashi Mizokami
Jun 11, 2015·Emerging Microbes & Infections·Zixiong LiGuangwen Cao
Aug 2, 2013·Memórias do Instituto Oswaldo Cruz·Alexander Augusto MartinezJuan Miguel Pascale
Jun 13, 2018·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Sanae HayashiYasuhito Tanaka
Sep 7, 2013·Journal of Medical Virology·Michael O BacligFilipinas F Natividad
Nov 18, 2015·World Journal of Gastroenterology : WJG·Rosa ZampinoNicola Coppola
May 24, 2021·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Jonas Michel WolfVagner Ricardo Lunge

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