Transmission of hepatitis C virus by anti-HCV-negative blood transfusion. Case report

Vox Sanguinis
H VrielinkP N Lelie

Abstract

Acute posttransfusion hepatitis C was reported in a recipient of 3 units of red cells. The recipient became acutely icteric 6 weeks after transfusion, and HCV infection was diagnosed. Stored serum samples of the 3 implicated donations, which were negative with ELISA-2, were retested by PCR and 3rd-generation antibody tests. One implicated donation was PCR positive, but anti-HCV negative. Both other donations were negative in all tests. The donor was recalled to the Blood Bank 13 weeks after the implicated donation and was found to be ELISA-3 plus RIBA-3 positive. Eight months after the implicated donation, the donor is still PCR and RIBA-3 positive, whereas the recipient became PCR negative but remained anti-HCV RIBA-3 positive. The case shows that blood products from donors collected during the open window period of an HCV infection can transmit HCV to recipients.

References

Jan 1, 1992·Vox Sanguinis·C L van der PoelM Houghton
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Jul 24, 1993·Lancet·D BrestersP N Lelie

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Citations

Mar 1, 1997·Journal of Virological Methods·J PetrikJ P Allain
Jul 16, 1999·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·T J LeglerK H Heermann
Jan 1, 1995·Vox Sanguinis·M DamenH W Reesink
Jan 1, 1996·Vox Sanguinis·A D KitchenA M Gorman
Aug 15, 1998·Vox Sanguinis·H H Lee, J P Allain
Apr 13, 2000·Clinical and Laboratory Haematology·J P Allain
Jun 26, 2003·Transfusion·Isidro Prat ArrojoIsabel Vidales Mancha
Sep 26, 2003·Transfusion·Eva A OperskalskiUNKNOWN Retrovirus Epidemiology Donor Study
Jun 11, 2004·Liver International : Official Journal of the International Association for the Study of the Liver·D SiagrisCh Labropoulou-Karatza
May 1, 1996·Journal of Pediatric Surgery·S P Nelson, M M Jonas
Feb 14, 1998·Transfusion Medicine Reviews·J P Allain
Dec 5, 2000·Baillière's Best Practice & Research. Clinical Haematology·J P Allain
Feb 25, 2000·Biologicals : Journal of the International Association of Biological Standardization·M S CardosoB Kubanek
Nov 1, 2005·Journal of Viral Hepatitis·L BrantUNKNOWN HCV National Register Steering Group*

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