Transmission of hepatitis C virus by transfusion in Orebro County, Sweden, 1990-1992

Scandinavian Journal of Infectious Diseases
R NordaP Olcén

Abstract

A retrospective study of hepatitis C virus (HCV) transmission by transfusion was conducted in Orebro county. Out of the 7,900 active, registered blood donors, 21 repeatedly anti-HCV reactive (RIVA 2 positive or indeterminate) donors were diagnosed. Their 84 recipients from January 1990 through June 1992 were identified and 41 (49%) were alive in December 1992. A total of 13 anti-HCV reactive (RIBA 2 positive or indeterminate) were diagnosed in 39 investigated recipients. Of these 11 were previously undiagnosed, and seven were HCV RNA-positive. In the donor population 1.03% were anti-HCV-positive by ELISA, but only 0.09% were RIBA and HCV RNA-positive. In 1990, 0.06% of the blood components came from the HCV RNA-positive donors, and none during the first 6 months of 1992. In order to identify transfusion-transmitted HCV infections that took place before the introduction of tests for anti-HCV antibodies, patients with a history of transfusion and symptoms and signs of liver dysfunction or damage should be thoroughly tested.

References

Nov 1, 1991·Journal of Hepatology·S DittmannF Deinhardt
Jan 1, 1994·Vox Sanguinis·H L ZaaijerP N Lelie

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Citations

Jul 26, 2003·Transfusion Medicine Reviews·Eleftherios C Vamvakas
Feb 26, 1999·Transfusion·A LongM Goldman
Jun 16, 2001·Transfusion·A Pereira
Jul 31, 2002·Transfusion·Eleftherios C Vamvakas, Rosalyn Goldstein
Feb 18, 2010·Journal of Viral Hepatitis·A-S DubergS M Montgomery
Dec 18, 2014·Scandinavian Journal of Gastroenterology·Ann-Sofi DubergSoo Aleman
Feb 8, 2006·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Lilia LópezNilo Bentancor
May 5, 1998·Transfusion Medicine Reviews·M GoldmanG Spurll
Feb 15, 2019·Acta Oncologica·Afrodite Psaros EinbergBjörn Fischler
Jul 29, 2020·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·Viktor DahlGustaf Edgren
Mar 8, 2011·Scandinavian Journal of Infectious Diseases·Magdalena YdreborgMartin Lagging

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