Transmission of HIV-1 and HLA-B allele-sharing within serodiscordant heterosexual Zambian couples

Lancet
M Tevfik DorakR A Kaslow

Abstract

Factors that might increase risk of HIV-1 transmission include age, sex, and amount of HIV-1 RNA in plasma, but findings for HLA allele-sharing are not in agreement. We tested the hypothesis that allele sharing at HLA loci is associated with increased risk of transmission of HIV-1 infection in cohabiting heterosexual Zambian couples. We studied 125 initially serodiscordant partners with sequence-confirmed interpartner HIV-1 transmission and 104 couples who were persistently serodiscordant, and we analysed relations with molecularly typed HLA-A, B, and C alleles by survival techniques. After adjustment for other genetic and non-genetic risk factors seen with heterosexual transmission of HIV-1 in this cohort, sharing of HLA-B alleles was independently associated with accelerated intracouple transmission (relative hazard 2.23, 95% CI 1.52-3.26, p<0.0001). Selective pressure by HLA-B alleles on transmitted viruses accords with current understanding of the effect of B locus polymorphism in HIV-1 and perhaps other infections.

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Citations

Jun 1, 2006·Journal of Urban Health : Bulletin of the New York Academy of Medicine·M MarmorM Vogler
Jun 16, 2005·Current Opinion in Immunology·Cynthia A Derdeyn, Guido Silvestri
May 14, 2008·The Journal of Experimental Medicine·Susan Allen
Jan 5, 2005·The Journal of Infectious Diseases·Richard A KaslowJames Jianming Tang
May 9, 2008·The Journal of Infectious Diseases·Romel D MackelprangCarey Farquhar
Dec 20, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Judith DalmauJavier Martinez-Picado
Jun 26, 2007·AIDS·Piyush Tripathi, Suraksha Agrawal
Aug 5, 2008·Retrovirology·Andrea MatucciDonato Zipeto
Mar 15, 2014·PLoS Computational Biology·Nico J D NagelkerkeSake J de Vlas
May 3, 2014·PLoS Pathogens·Emma HodcroftUNKNOWN UK CHIC Study
Jan 11, 2013·Clinical & Developmental Immunology·Johanne PoudrierMichel Roger
Nov 22, 2014·The Journal of Infectious Diseases·Manish Sagar
May 1, 2006·Current Opinion in HIV and AIDS·Noureddine Berka, Richard A Kaslow
Aug 16, 2006·The Nursing Clinics of North America·Felissa R Lashley
Nov 21, 2015·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Steffanie SabbajPaul A Goepfert
Dec 20, 2008·Journal of Internal Medicine·L PiacentiniM Clerici
Feb 21, 2006·Clinical and Experimental Immunology·W JennesL Kestens
Jan 5, 2005·Trends in Immunology·Henry A F Stephens
Jul 10, 2018·F1000Research·Yufei Wang
Jan 13, 2018·Journal of Virology·Zachary EndeEric Hunter
Nov 4, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Wim JennesLuc Kestens
Jan 1, 2019·Current Immunology Reviews·Kattayoun KordyGrace M Aldrovandi

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