Abstract
Human respiratory syncytial virus (HRSV) causes substantial morbidity and mortality in vulnerable patients, such as the very young, the elderly, and immunocompromised individuals of any age. Nosocomial transmission of HRSV remains a serious challenge in hospital settings, with intervention strategies largely limited to infection control measures, including isolation of cases, high standards of hand hygiene, cohort nursing, and use of personal protective equipment. No vaccines against HRSV are currently available, and treatment options are largely supportive care and expensive monoclonal antibody or antiviral therapy. The limitations of current animal models for HRSV infection impede the development of new preventive and therapeutic agents, and the assessment of their potential for limiting HRSV transmission, in particular in nosocomial settings. Here, we demonstrate the efficient transmission of HRSV from immunocompromised ferrets to both immunocompromised and immunocompetent contact ferrets, with pathological findings reproducing HRSV pathology in humans. The immunocompromised ferret-HRSV model represents a novel tool for the evaluation of intervention strategies against nosocomial transmission of HRSV.
References
Jan 1, 1991·Journal of Clinical Microbiology·J A EnglundF S Rhame
Jul 10, 1986·The New England Journal of Medicine·C B HallH J Cohen
Mar 23, 2010·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Christelle KassisRoy F Chemaly
Apr 13, 2010·Bone Marrow Transplantation·V LavergneC Béliveau
Dec 9, 2010·Blood·Jharna N Shah, Roy F Chemaly
Jun 7, 2011·The American Journal of Pathology·Rogier BodewesThijs Kuiken
Jan 21, 2012·Veterinary Pathology·J M A van den BrandT Kuiken
Sep 21, 2012·Scandinavian Journal of Infectious Diseases·Rogier A S HoekMenno M van der Eerden
Oct 27, 2012·Journal of Clinical Microbiology·Steffen GeisPaul Schnitzler
Nov 14, 2012·Pediatrics·Roberto P SantosMartha L Lepow
May 30, 2013·PLoS Pathogens·Erhard van der VriesAlbert D M E Osterhaus
Feb 24, 2016·Influenza and Other Respiratory Viruses·Clare E FrenchCharles R Beck
Jun 18, 2016·Viruses·Koert J StittelaarRik L de Swart
Dec 3, 2016·Vaccine·Geraldine Taylor
May 31, 2017·The Journal of Hospital Infection·T InksterR Soutar
Jul 12, 2017·Lancet·Ting ShiUNKNOWN RSV Global Epidemiology Network
Dec 1, 2017·Journal of Virology·Kok Fei ChanPatrick C Reading
Citations
Jul 10, 2019·PloS One·Wiriya MahikulWirichada Pan-Ngum
Jul 22, 2020·The Journal of General Virology·Laurine C RijsbergenRory D de Vries
Oct 5, 2019·Influenza and Other Respiratory Viruses·Julius WongStephen J Kent
May 28, 2019·Frontiers in Microbiology·María José Altamirano-LagosAlexis M Kalergis
Jan 21, 2021·MBio·Alison E StoutGary R Whittaker
May 9, 2021·Journal of Theoretical Biology·Benjamin Jessie, Hana M Dobrovolny