PMID: 9557681Apr 29, 1998Paper

Transmission of human T-cell leukemia virus type 1 to mice

Journal of Virology
J FangM Miwa

Abstract

Human T-cell leukemia virus type 1 (HTLV-1) is associated with adult T-cell leukemia/lymphoma, HTLV-1-associated myelopathy/tropical spastic paraparesis, and other diseases. For prevention of the transmission of HTLV-1 and manifestation of these diseases, a small-animal model, especially a mouse model, would be useful. We injected HTLV-1-producing T cells (MT-2) intraperitoneally into neonatal C3H/HeJ mice. While the antibody against HTLV-1 antigens was not detectable in C3H/HeJ mice, HTLV-1 provirus was frequently detected in the spleen, lymph nodes, and thymus by PCR. HTLV-1 provirus was present at the level of 0 to 30 molecules in 10(5) spleen cells at the age of 15 weeks. In addition, a 59-bp flanking sequence of the HTLV-1 integration site was amplified from the spleen DNA by linker-mediated PCR and was confirmed to be derived from the mouse genome. HTLV-1 provirus was found in the T-cell fraction of the mouse spleen. These results indicate that mice can be infected by HTLV-1 and could serve as an animal model for the study of HTLV-1 infection and its pathogenesis in vivo.

References

Mar 1, 1992·Japanese Journal of Cancer Research : Gann·M MochizukiN Miyata
Nov 11, 1991·International Journal of Cancer. Journal International Du Cancer·T SugaK Uchida
Jan 1, 1991·Leukemia Research·A SetoK Ogawa
Feb 25, 1989·Lancet·K NishiokaM Osame
Jun 15, 1986·International Journal of Cancer. Journal International Du Cancer·S KotaniI Miyoshi
Feb 15, 1985·Cancer·F KawanoK Takatsuki
May 15, 1985·Cancer·R YoshiokaK Takatsuki
Jan 1, 1984·Medical Microbiology and Immunology·N YamamotoY Hinuma
Oct 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·H HoshinoT Sugimura
Dec 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·B J PoieszR C Gallo
Oct 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·Y HinumaI Miyoshi
Mar 14, 1996·Nature·E Jordan, F S Collins
Mar 14, 1996·Nature·W F DietrichT J O'Connor
Apr 28, 1997·Biochemical and Biophysical Research Communications·J FangM Miwa

❮ Previous
Next ❯

Citations

Sep 13, 2005·Oncogene·Nicolas ManelMarc Sitbon
Feb 16, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Jill VanmassenhoveFadi Fakhouri
Jan 1, 2011·Experimental and Therapeutic Medicine·Masakazu TanakaMasanao Miwa
Jan 1, 2013·Virology : Research and Treatment·Amanda R PanfilPatrick L Green
Jul 20, 2019·Journal of Radiation Research·Masakazu TanakaMasanao Miwa
Aug 1, 2002·Japanese Journal of Cancer Research : Gann·Binlian SunMasanao Miwa
May 11, 2001·Japanese Journal of Cancer Research : Gann·R FengM Miwa
Apr 13, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Saifur RahmanPooja Jain
Mar 17, 1999·Japanese Journal of Cancer Research : Gann·R FengM Miwa
Aug 8, 2021·International Journal of Molecular Sciences·Greta ForlaniMaria Grazia Romanelli

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.