PMID: 2500394Jul 1, 1989Paper

Transmission of hypertension in rats by cross circulation

Hypertension
W ZidekU Heckmann

Abstract

Cross circulation was performed in 54 couples of spontaneously hypertensive and normotensive rats. Blood was pumped through two anastomoses between the carotid arteries and external jugular veins in both directions with equal flow rate. In normotensive rats cross-circulated with untreated spontaneously hypertensive rats mean arterial pressure increased by 20.9 +/- 12.2 mm Hg (p less than 0.01). Administration of digoxin antibody in a dose binding 0.25 mg digoxin to the spontaneously hypertensive rats before cross circulation prevented the transmission of hypertension to the normotensive rat, whereas chemical sympathectomy with 6-hydroxydopamine and intravenous injection of inactive Fab fragments had no inhibitory effect. It is concluded that, in this strain of spontaneously hypertensive rats, a circulating hypertensive factor exists. The factor binds to digoxin antibody and is not produced in sympathetic nervous tissue.

References

Jul 1, 1975·The Journal of Clinical Endocrinology and Metabolism·A M MichelakisT Inagami
Dec 17, 1985·Biochemical and Biophysical Research Communications·T ImadaT Inagami
Jan 1, 1986·Clinical and Experimental Hypertension. Part A, Theory and Practice·W ZidekH Vetter
Jan 1, 1985·Clinical and Experimental Hypertension. Part A, Theory and Practice·F J Haddy, M B Pamnani
Jan 1, 1985·Clinical and Experimental Hypertension. Part A, Theory and Practice·J M KrzesinskiG L Rorive
Oct 1, 1985·Canadian Journal of Physiology and Pharmacology·W D McCumbee, G L Wright
Jan 1, 1974·Kidney International·V M Buckalew, D B Nelson
Jan 1, 1981·Clinical and Experimental Hypertension : CHE·L PostonP J Hilton
Mar 1, 1984·Journal of Cardiovascular Pharmacology·W D Matthews, G P McCafferty
Apr 16, 1984·Life Sciences·G L Wright, W D McCumbee
Dec 1, 1981·Clinical Science·P L PadfieldJ I Robertson
Aug 1, 1958·The American Journal of the Medical Sciences·G D'AMICO
Apr 15, 1960·Klinische Wochenschrift·H LOSSEF WESSELS

❮ Previous
Next ❯

Citations

Jun 16, 1999·Clinical and Experimental Hypertension : CHE·M NeusserM Tepel
Jan 1, 1991·Clinical and Experimental Hypertension. Part A, Theory and Practice·S D Gray
Jan 1, 1992·Clinical and Experimental Hypertension. Part A, Theory and Practice·J L AndradeF Vargas
Jan 11, 2000·Circulation Research·C H GelbandM K Raizada
Mar 7, 2002·Journal of the Renin-angiotensin-aldosterone System : JRAAS·M GardonC H Gelband
Jan 1, 1992·Clinical and Experimental Hypertension. Part A, Theory and Practice·W Schoner

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.