Transmission of novel influenza A(H1N1) in households with post-exposure antiviral prophylaxis.

PloS One
Michiel van BovenJacco Wallinga

Abstract

Despite impressive advances in our understanding of the biology of novel influenza A(H1N1) virus, little is as yet known about its transmission efficiency in close contact places such as households, schools, and workplaces. These are widely believed to be key in supporting propagating spread, and it is therefore of importance to assess the transmission levels of the virus in such settings. We estimate the transmissibility of novel influenza A(H1N1) in 47 households in the Netherlands using stochastic epidemic models. All households contained a laboratory confirmed index case, and antiviral drugs (oseltamivir) were given to both the index case and other households members within 24 hours after detection of the index case. Among the 109 household contacts there were 9 secondary infections in 7 households. The overall estimated secondary attack rate is low (0.075, 95%CI: 0.037-0.13). There is statistical evidence indicating that older persons are less susceptible to infection than younger persons (relative susceptibility of older persons: 0.11, 95%CI: 0.024-0.43. Notably, the secondary attack rate from an older to a younger person is 0.35 (95%CI: 0.14-0.61) when using an age classification of <or=12 versus >12 years, and 0.28 (95%...Continue Reading

References

Jun 1, 1985·American Journal of Epidemiology·A S MontoI M Longini
May 1, 1982·American Journal of Epidemiology·I M LonginiJ P Fox
Oct 28, 1999·The New England Journal of Medicine·F G HaydenR G Mills
Feb 15, 2001·JAMA : the Journal of the American Medical Association·R WelliverUNKNOWN Oseltamivir Post Exposure Prophylaxis Investigator Group
Aug 5, 2005·Science·Ira M LonginiM Elizabeth Halloran
Jan 31, 2006·Lancet·T JeffersonA Rivetti
Apr 28, 2006·Nature·Neil M FergusonDonald S Burke
Sep 14, 2006·American Journal of Epidemiology·Jacco WallingaMirjam Kretzschmar
Nov 8, 2006·American Journal of Epidemiology·M Elizabeth HalloranArnold S Monto
Aug 7, 2007·PLoS Computational Biology·Michiel van BovenHans J A P Heesterbeek
Jan 31, 2008·American Journal of Epidemiology·Fabrice CarratAlain-Jacques Valleron
Dec 10, 2008·Journal of the Royal Society, Interface·Kathryn Glass, Niels G Becker
Feb 11, 2009·Proceedings of the National Academy of Sciences of the United States of America·Jeffrey Shaman, Melvin Kohn
May 13, 2009·Science·Christophe FraserUNKNOWN WHO Rapid Pandemic Assessment Collaboration
Jun 23, 2009·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Adam MeijerMarion Koopmans
Jul 1, 2009·The New England Journal of Medicine·Gerardo ChowellMark A Miller
Jul 16, 2009·BMJ : British Medical Journal·Tini GarskeAzra C Ghani
Nov 12, 2009·Influenza and Other Respiratory Viruses·Laura Forsberg WhiteMarcello Pagano
Dec 23, 2009·PLoS Currents·Joshua L CherryYuri I Wolf
Dec 24, 2009·PLoS Currents·Edward GoldsteinMarc Lipsitch
Jan 1, 2010·The New England Journal of Medicine·Simon CauchemezNeil M Ferguson
Nov 22, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Yuuki TsuchihashiNobuhiko Okabe
May 1, 2006·Journal of the Royal Statistical Society. Series C, Applied Statistics·Yang YangM Elizabeth Halloran
Sep 22, 2012·Antimicrobial Resistance and Infection Control·Arianne B van Gageldonk-LafeberUNKNOWN Dutch ZonMw Influenza A(H1N1) 2009 consortium

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Citations

Aug 17, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Michael L JacksonStephanie J Schrag
Jan 1, 2013·Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·M A B van der SandeM van der Lubben
Jan 23, 2013·Epidemiology·Dennis E te BeestMichiel van Boven
Nov 24, 2011·Scandinavian Journal of Infectious Diseases·Benjamin TehJoseph Torresi
Nov 28, 2015·Trends in Microbiology·Tim K TsangBenjamin J Cowling
Nov 29, 2011·Influenza and Other Respiratory Viruses·Ashry G MohamedHytham Al-Saif
Sep 23, 2014·Epidemics·Axel A Bonačić MarinovićMirjam Kretzschmar
May 10, 2017·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Chen-Yi ChuLiu-Yu Huang
Mar 8, 2018·PLoS Computational Biology·Elizabeth C LeeShweta Bansal
Apr 21, 2016·PloS One·Özgür ÖzmenJames J Nutaro

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Methods Mentioned

BETA
PCR

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