Transmission of SARS-CoV-2 in domestic cats imposes a narrow bottleneck.

PLoS Pathogens
K. M. BraunThomas Friedrich

Abstract

The evolutionary mechanisms by which SARS-CoV-2 viruses adapt to mammalian hosts and, potentially, undergo antigenic evolution depend on the ways genetic variation is generated and selected within and between individual hosts. Using domestic cats as a model, we show that SARS-CoV-2 consensus sequences remain largely unchanged over time within hosts, while dynamic sub-consensus diversity reveals processes of genetic drift and weak purifying selection. We further identify a notable variant at amino acid position 655 in Spike (H655Y), which was previously shown to confer escape from human monoclonal antibodies. This variant arises rapidly and persists at intermediate frequencies in index cats. It also becomes fixed following transmission in two of three pairs. These dynamics suggest this site may be under positive selection in this system and illustrate how a variant can quickly arise and become fixed in parallel across multiple transmission pairs. Transmission of SARS-CoV-2 in cats involved a narrow bottleneck, with new infections founded by fewer than ten viruses. In RNA virus evolution, stochastic processes like narrow transmission bottlenecks and genetic drift typically act to constrain the overall pace of adaptive evolution. ...Continue Reading

References

Apr 29, 1999·Proceedings of the National Academy of Sciences of the United States of America·C T BergstromL A Real
Jun 12, 2003·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·S F ElenaP E Turner
Dec 8, 2006·The Journal of Infectious Diseases·Yasuhito Tanaka, Masashi Mizokami
Dec 3, 2014·Cell Host & Microbe·Andrew VarbleBenjamin R tenOever
Apr 9, 2015·Nature Communications·Hassan ZaraketRichard J Webby
Mar 10, 2016·Annual Review of Virology·Mark P Zwart, Santiago F Elena
Sep 22, 2017·The Journal of Infectious Diseases·Maki KisoYoshihiro Kawaoka
Nov 7, 2017·Current Opinion in Virology·John T McCrone, Adam S Lauring
Jan 20, 2018·Proceedings of the National Academy of Sciences of the United States of America·Jing YanUNKNOWN EMIT Consortium
Jan 5, 2019·Reviews in Medical Virology·Alireza TahamtanVahid Salimi
Feb 7, 2019·Virus Evolution·Lei Zhao, Christopher J R Illingworth
May 14, 2020·The New England Journal of Medicine·Peter J HalfmannYoshihiro Kawaoka
May 21, 2020·Nature·Xiaonan ZhangHongzhou Lu
May 29, 2020·Medical Hypotheses·Subrata K Biswas, Sonchita R Mudi
May 30, 2020·Science·Seema S Lakdawala, Vineet D Menachery
Jun 20, 2020·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·Nadia OreshkovaArjan Stegeman
Jun 20, 2020·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·María Pilar GuallarVicente Soriano
Jul 10, 2020·Nature Communications·Mathilde RichardSander Herfst
Aug 2, 2020·Journal of General Internal Medicine·Monica GandhiEric Goosby
Aug 21, 2020·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Timokratis KaramitrosAndreas Mentis
Sep 23, 2020·Proceedings of the National Academy of Sciences of the United States of America·Jason W RauschMary F Kearney

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Citations

Apr 3, 2021·Nature Reviews. Immunology·Sarah CobeyMarc Lipsitch
May 21, 2021·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·Erik BoehmUNKNOWN Geneva Centre for Emerging Viral Diseases
Jun 3, 2021·Viruses·Anna Winger, Thomas Caspari
May 13, 2021·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Gage K MorenoDavid H O'Connor
Jul 29, 2021·The Veterinary Quarterly·Khan SharunKuldeep Dhama
Aug 8, 2021·Animals : an Open Access Journal From MDPI·Sebastian Giraldo-RamirezJulian Ruiz-Saenz

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