Transmission of "split anergy" from tumor infiltrating to peripheral NK cells in a manner similar to "infectious tolerance"

Medical Hypotheses
Nikolai N Belyaev, Vera A Abramova

Abstract

According to a new paradigm of carcinogenesis, a tumor arises not from transformed cell, but only from tumor initiating cells called cancer stem cells (CSCs), which can originate from tissue stem cells. CSC are resistant to conventional therapy and after treatment form new tumors and give rise to metastases. Only natural killer (NK) cells are capable of lysing CSCs, but within different tumor types these cells experience a condition known as "split anergy", whereby the NK cells lose the ability to kill CSCs and being to produce cytokines. As a result, uncontrolled tumor growth arises and tumor stroma accumulates anergic NK cells. We hypothesize that anergic tumor infiltrating NK (TINK) cells transmit their property to naïve NK cells by infecting" them with a state of "split anergy" in a similar manner as T conventional cells are transformed into T regulatory cells during the process of "infectious tolerance". Anergic TINK cells egress from the tumor stroma via the lymphatic system, where they reach regional lymph nodes and transmit their properties to naïve NK cells, which in turn become anergic toward CSCs and lose immunosurveillance functions. The mechanisms proposed for this hypothesis and the methodological approaches for c...Continue Reading

References

May 13, 1999·Proceedings of the National Academy of Sciences of the United States of America·O MandelboimJ L Strominger
Mar 7, 2001·Lancet·F Balkwill, A Mantovani
Jan 28, 2003·Trends in Immunology·Barbara SeligerSoldano Ferrone
Mar 11, 2004·American Journal of Physiology. Gastrointestinal and Liver Physiology·Mairi MacarthurEmad M El-Omar
Feb 21, 2006·Cancer Research·Max S WichaGabriela Dontu
May 26, 2006·Nature Reviews. Cancer·Angelo L VescoviBrent A Reynolds
Jun 24, 2006·Journal of Leukocyte Biology·Nadja E Tobler, Michael Detmar
Aug 22, 2006·Molecular Carcinogenesis·Dean G TangCollene Jeter
Nov 15, 2006·Immunological Reviews·Yenan T BrycesonEric O Long
Jun 6, 2007·Proceedings of the National Academy of Sciences of the United States of America·Piero DalerbaMichael F Clarke
Jul 13, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Carol TangShazib Pervaiz
Jul 25, 2007·Annual Review of Cell and Developmental Biology·Neethan A LoboMichael F Clarke
Sep 6, 2007·Cell Cycle·Lauren L Campbell, Kornelia Polyak
Oct 25, 2007·Biochemical Society Transactions·H G Jørgensen, T L Holyoake
Jan 15, 2008·Immunologic Research·Steven J BurgessJohn E Coligan
Apr 9, 2008·Current Gene Therapy·Camilla Ribacka, Akseli Hemminki
Jun 12, 2008·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·Emmanuelle Charafe-JauffretMax S Wicha
Dec 17, 2008·Physiology·Michael Quante, Timothy Cragin Wang
Jan 20, 2009·Current Stem Cell Research & Therapy·Harikrishna NakshatriSunil Badve
Mar 10, 2009·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Md Zahidunnabi DewanMasakazu Toi
Apr 8, 2009·The Journal of Clinical Investigation·Tadepally LakshmikanthFrancesco Colucci
May 6, 2009·Stem Cells·Shigeo TakaishiTimothy C Wang
Jun 6, 2009·International Immunology·Gabriella PietraMaria Cristina Mingari
Aug 12, 2009·Cancer Immunology, Immunotherapy : CII·Jennifer Konopa Mulligan, M Rita I Young
Oct 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Giulia BertoliniGabriella Sozzi
Oct 10, 2009·Proceedings of the National Academy of Sciences of the United States of America·Noa StanietskyOfer Mandelboim
Feb 11, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Ralf DresselWolfgang Engel
Feb 25, 2010·Cell·Tuomas Tammela, Kari Alitalo
Mar 23, 2010·Cell·Sergei I GrivennikovMichael Karin
Jun 3, 2010·International Journal of Cancer. Journal International Du Cancer·Hiroyoshi Nishikawa, Shimon Sakaguchi
Jun 12, 2010·European Journal of Immunology·Catrine M Persson, Benedict J Chambers
Jul 1, 2010·Stem Cell Research & Therapy·Julie M Chandler, Eric Lagasse
Dec 15, 2010·Translational Oncology·Heather D CunninghamCharlotte M Vines
Jan 12, 2011·Proceedings of the National Academy of Sciences of the United States of America·Dimitrios IliopoulosKevin Struhl
Jan 13, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Giulia FregniAnne Caignard
Feb 15, 2011·Journal of Oncology·Aurelio Lorico, Germana Rappa

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Citations

Sep 1, 2020·Immunological Investigations·Yekaterina O OstapchukNikolai N Belyaev

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