Transmission-recovery trade-offs to study parasite evolution

The American Naturalist
S Alizon

Abstract

Parasite evolution is mainly studied through a trade-off involving host death (i.e., virulence) and transmission. In addition to the lack of evidence, this trade-off largely fails to understand the evolution of sublethal parasite effects. Here, I argue that considering host recovery as a main selection pressure faced by the parasite helps to address these problems and opens new perspectives for the study of parasite evolution. Using an embedded model, I show how a trade-off between transmission and recovery may emerge from within-host dynamics if immune activation is assumed to depend on the parasite's overall growth rate. I also show that the value of the parasite's optimal growth rate strongly depends on the immunological state of the host. Transmission-recovery trade-offs are of particular interest to the study of the evolution of human pathogens because of the use of antipathogen treatments, which strengthens the recovery constraint.

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Citations

Jun 24, 2010·Vector Borne and Zoonotic Diseases·Lisa E SchwanzRichard S Ostfeld
Nov 28, 2014·Proceedings. Biological Sciences·Carmen Lía MurallTroy Day
Nov 19, 2013·Trends in Microbiology·Kristofer Wollein Waldetoft, Lars Råberg
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Apr 19, 2018·Journal of Evolutionary Biology·Tsukushi KamiyaSamuel Alizon
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Jul 2, 2021·Journal of Evolutionary Biology·Samuel Alizon, Mircea T Sofonea
Aug 11, 2021·Proceedings. Biological Sciences·Elisa VisherMichael Boots
Sep 17, 2021·Journal of Theoretical Biology·Ruili Fan, Stefan A H Geritz

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