Transmission-reducing immunity is inversely related to age in Plasmodium falciparum gametocyte carriers

Parasite Immunology
C J DrakeleyR W Sauerwein

Abstract

Immunity to the sexual stages of Plasmodium falciparum is induced during natural infections and can significantly reduce the transmission of parasites to mosquitoes (transmission reducing activity; TRA) but little is known about how these responses develop with increasing age/exposure to malaria. Routinely TRA is measured in the standard membrane feeding assay (SMFA). Sera were collected from a total of 199 gametocyte carriers (median age 4 years, quartiles 2 and 9 years) near Ifakara, Tanzania; 128 samples were tested in the SMFA and generated TRA data classified as a reduction of > 50% and > 90% of transmission. TRA of > 50% was highest in young children (aged 1-2) with a significant decline with age (chi(2) trend = 5.79, P = 0.016) and in logistic regression was associated with prevalence of antibodies to both Pfs230 and Pfs48/45 (OR 4.03, P = 0.011 and OR 2.43 P = 0.059, respectively). A TRA of > 90% reduction in transmission was not age related but was associated with antibodies to Pfs48/45 (OR 2.36, P = 0.055). Our data confirm that antibodies are an important component of naturally induced TRA. However, whilst a similar but small proportion of individuals at all ages have TRA > 90%, the gradual deterioration of TRA > 50%...Continue Reading

References

Jan 1, 1987·Journal of Clinical Microbiology·G Del GiudiceH D Engers
Apr 1, 1989·Parasitology·T PonnuduraiJ H Meuwissen
Jan 1, 1987·Transactions of the Royal Society of Tropical Medicine and Hygiene·T PonnuduraiJ H Meuwissen
Jan 1, 1982·Transactions of the Royal Society of Tropical Medicine and Hygiene·T PonnuduraiJ H Meuwissen
Aug 1, 1993·Current Opinion in Immunology·D C Kaslow
May 1, 1993·Transactions of the Royal Society of Tropical Medicine and Hygiene·C Rogier, J F Trape
Jan 1, 1996·Transactions of the Royal Society of Tropical Medicine and Hygiene·A LensenR Sauerwein
Jul 31, 1998·Annals of Tropical Medicine and Parasitology·J K Baird
Aug 26, 1998·The American Journal of Tropical Medicine and Hygiene·T SmithM Tanner
Nov 24, 1999·Infection and Immunity·K P PiperK P Day
Jun 5, 2001·The American Journal of Tropical Medicine and Hygiene·N I AkimR W Sauerwein
Jun 19, 2004·Malaria Journal·J Teun BousemaRobert W Sauerwein
Sep 14, 2004·Immunological Reviews·Siske S Struik, Eleanor M Riley
Sep 16, 2004·Parasite Immunology·C J DrakeleyG A T Targett

❮ Previous
Next ❯

Citations

Mar 29, 2011·Journal of Mathematical Biology·Julien ArinoPascal Zongo
Sep 13, 2013·BMC Infectious Diseases·Lindsay T Keegan, Jonathan Dushoff
Feb 19, 2016·Malaria Journal·Daniel Gonçalves, Patrick Hunziker
Jan 9, 2016·Parasitology·Will J R StoneSanna R Rijpma
Nov 30, 2010·International Journal for Parasitology·Shusuke NakazawaYoshimasa Maeno
Dec 19, 2014·Malaria Journal·Sarah BoudováMiriam K Laufer
Oct 18, 2016·The Indian Journal of Medical Research·Neha ChaturvediNeeru Singh
Jan 4, 2017·Expert Review of Vaccines·Michael TheisenRobert Sauerwein
Feb 10, 2018·Nature Communications·Will J R StoneMatthijs M Jore
Mar 1, 2017·Cold Spring Harbor Perspectives in Medicine·Teun Bousema, Chris Drakeley
Aug 2, 2007·Molecular Psychiatry·J A Gray, B L Roth
Dec 17, 2019·Immunological Reviews·Roos M de JongTeun Bousema
Jun 7, 2019·Science Translational Medicine·Kathleen W DantzlerMatthias Marti
Apr 10, 2019·Infection and Immunity·Festus K AcquahLinda E Amoah
Oct 3, 2017·The Journal of Infectious Diseases·Edward EssumanSanjai Kumar
Oct 23, 2019·Frontiers in Immunology·Bergeline C Nguemwo TentokamCamila H Coelho
Feb 26, 2019·Frontiers in Immunology·Jonas A Kengne-OuafoBismarck Dinko
Jan 13, 2021·Expert Review of Vaccines·Palak N Patel, Niraj Tolia
Mar 17, 2018·Trends in Parasitology·Cristian Koepfli, Guiyun Yan
Nov 3, 2021·Scientific Reports·Ruth Ayanful-TorgbyLinda E Amoah

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.