Transmission transmissible hepatitis B virus markers of infection among sickle cell disease patients receiving care at a tertiary health facility in Ibadan, southwest Nigeria

Journal of Immunoassay & Immunochemistry
Adeleye Solomon BakareyY A Aken'Ova

Abstract

Hepatitis B virus infection attacks the liver and can cause both acute and chronic disease. Sickle cell disease (SCD) patients are at risk of transmission transmissible viral hepatitis due to their constant need for blood transfusion. However, these patients could have been infected with HBV but may not know their status due to asymptomatic nature of the infection. Therefore, this study was designed to determine the burden of HBV markers of infection among SCD patients attending the hematology clinic at a tertiary health facility in Ibadan, Nigeria. A cross-sectional study was investigated among 112 consenting SCD patients (M = 45; F = 67) age ranged 15-60 years (mean age = 26.9; mean PCV = 24 ± 4.8) attending a hematology clinic at the University College Hospital, Ibadan. A structured questionnaire was administered to capture demographic and other relevant information. Blood samples from each participant were tested for HBV markers by ELISA technique, while data were analyzed using SPSS version 21 with P < 0.05 considered significant. A total of 5 (4.5%), 0 (0.0%), and 15 (13.4%) were positive for HBsAg, HBeAg, and HBeAb, respectively. Also, 63 (56.3%) of the participants have never been transfused, while 49 (43.8%) had receiv...Continue Reading

References

Aug 4, 2001·Emerging Infectious Diseases·M E ChamberlandM Ricketts
Oct 24, 2001·Antiviral Research·S J Hadziyannis, D Vassilopoulos
Aug 31, 2002·Journal of Clinical Microbiology·William AmpofoKoichi Ishikawa
Oct 28, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·David Milich, T Jake Liang
Jun 12, 2004·Seminars in Liver Disease·Stephen Locarnini
Dec 7, 2010·Lancet·David C ReesMark T Gladwin
Aug 8, 2013·BMC Public Health·Emmanuel OcholaCharles Karamagi

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
ELISA

Software Mentioned

SPSS

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