PMID: 16685May 13, 1977

Transmitter histochemistry of the rat olfactory bulb. I. Immunohistochemical localization of monoamine synthesizing enzymes. Support for intrabulbar, periglomerular dopamine neurons

Brain Research
N HalászP Biberfeld

Abstract

The rat olfactory bulb was studied at the light and electron microscopic level with the indirect immunofluorescence technique and the unlabelled antibody enzyme method (PAP-technique), respectively. Antibodies to all 4 enzymes in the catecholamine synthesis were used. In the principal bulb the first two enzymes, tyrosine hydroxylase (TH) and DOPA decarboxylase (DDC), but not dopamine-beta-hydroxylase (DBH), were present in a proportion of periglomerular cell bodies and dendrites indicating that these neurons synthesize dopamine (DA). This amine may therefore be released as a transmitter substance at some of the intraglomerular dendrodendritic synapses which periglomerular cells form with the mitral cells. There is evidence to suggest that some periglomerular cells use GABA as their transmitter. Thus, a morphologically and physiologically homogenous population of neurons can be subdivided on the basis of transmitter histochemical criteria. There was an impression of more DDC-positive than TH-positive fibers in the glomeruli. Such presumably DDC-positive, but TH-negative processes may represent 5-hydroxytryptamine (5-HT) nerve terminals. DBH-positive fibers were seen in the granular, external plexiform, and very rarely, in the gl...Continue Reading

References

Jan 1, 1994·Experimental Brain Research·S P FracekR Schafer
Nov 18, 2008·Pflügers Archiv : European journal of physiology·Angela PignatelliOttorino Belluzzi
Jul 15, 2006·Journal of Neurocytology·Elke Weiler, Alia Benali
Dec 8, 1980·Brain Research·M T González-Estrada, W J Freeman
Jun 1, 1979·Electroencephalography and Clinical Neurophysiology·R Gervais
May 1, 1984·Electroencephalography and Clinical Neurophysiology·R GervaisJ F Pujol
Feb 1, 1990·Brain Research. Molecular Brain Research·M SchallingP Greengard
Jan 1, 1988·Progress in Neuro-psychopharmacology & Biological Psychiatry·G N Ervin, C B Nemeroff
Nov 1, 1983·Neuroscience·N Halász, G M Shepherd

Citations

Jan 1, 1976·Life Sciences·D Park, M Goldstein
Jun 30, 1975·Annals of the New York Academy of Sciences·T HökfeltM Goldstein
Jan 1, 1975·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·V M PickelD J Reis
May 1, 1975·Pharmacology, Biochemistry, and Behavior·K D CairncrossJ R Bassett
Mar 18, 1976·Nature·J KorfB H Westerink
Mar 18, 1976·Nature·L B GeffenL L Iversen
Apr 30, 1976·Brain Research·J Van der GugtenD H Versteeg
Aug 1, 1974·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·J P PetraliL A Sternberger
Oct 11, 1974·Nature·R RoskoskiF J Diecke
Aug 30, 1974·Brain Research·M J BrownsteinJ Axelrod
Nov 15, 1974·Brain Research·A Neidle, J Kandera
Sep 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·B K HartmanS Udenfriend
May 15, 1973·Life Sciences. Pt. 1: Physiology and Pharmacology·L T Graham
Aug 30, 1973·Zeitschrift Für Anatomie Und Entwicklungsgeschichte·A Seiger, L Olson
May 24, 1974·Science·F L Margolis
Jul 27, 1965·Histochemie. Histochemistry. Histochimie·T R Shanthaveerappa, G H Bourne
Oct 1, 1969·The Journal of Physiology·L B GeffenR A Rush
Jan 1, 1966·Experimental Neurology·W RallM W Brightman
Apr 1, 1966·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·R C Graham, M J Karnovsky
Sep 1, 1967·Brain : a Journal of Neurology·C C Shute, P R Lewis
Nov 8, 1958·Nature·C C CURTAIN
Feb 9, 1965·Zeitschrift für Zellforschung und mikroskopische Anatomie·K FUXE

Related Concepts

Congenital Abnormal Synostosis
Pnmt
Dopamine-beta-monooxygenase
Accessory Olfactory Bulb
Neurohormones
Phenylethanolamine N-Methyltransferase
DOPA decarboxylase
Intropin
Cytochemistry
Tyrosine 3-Monooxygenase

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Synapse Loss as Therapeutic Target in MS

As we age, the number of synapses present in the human brain starts to decline, but in neurodegenerative diseases this occurs at an accelerated rate. In MS, it has been shown that there is a reduction in synaptic density, which presents a potential target for treatment. Here is the latest research on synapse loss as a therapeutic target in MS.

Artificial Intelligence in Cardiac Imaging

Artificial intelligence (ai) techniques are increasingly applied to cardiovascular (cv) medicine in cardiac imaging analysis. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

Social Learning

Social learning involves learning new behaviors through observation, imitation and modeling. Follow this feed to stay up to date on the latest research.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Single Cell Chromatin Profiling

Techniques like ATAC-seq and CUT&Tag have the potential to allow single cell profiling of chromatin accessibility, histones, and TFs. This will provide novel insight into cellular heterogeneity and cell states. Discover the latest research on single cell chromatin profiling here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells.