PMID: 87242May 11, 1979

Transmitter histochemistry of the rat olfactory bulb III. Autoradiographic localization of [3H]GABA

Brain Research
N HalászTomas Hökfelt

Abstract

The distribution of [3H]gamma-aminobutyric acid (GABA) labeled elements in rat olfactory bulb was studied by light and electron microscopic autoradiography. [3H]GABA was strongly taken up into glial cells and pericytes in all layers of the bulb. The neuronal uptake of [3H]GABA was mainly seen in certain types of nerve terminals. About one-third of the granule dendritic terminals, some nerve endings of short axon cells, and certain nerve endings of extrabulbar origin showed a strong labeling. Labeling was seen in a small population of the periglomerular, short axon and granule cell bodies. Most cell bodies of these 3 types as well as the mitral cells did not, however, accumulate any appreciable amo9nt of [3H]GABA. The labeling pattern seen after injection of [3H]glycine and [3H]leucine was clearly different from the pattern seen after [3H]GABA injection. The labeling was more uniformly distributed over the components of the neuropil with a considerably higher activity over certain cell somata such as the mitral cells. The present results demonstrate that neuronal uptake and accumulation of [3H]GABA occur into populations of olfactory bulb cells and processes, which from neurophysiological and/or immunohistochemical studies are s...Continue Reading

References

Jan 1, 1991·Progress in Neurobiology·L Sivilotti, A Nistri
Nov 1, 1983·Neuroscience·N Halász, G M Shepherd
Jan 1, 1993·Brain Research Bulletin·G Z YuK Seto
Nov 1, 1996·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·R BetarbetM B Luskin
Apr 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·P SomogyiJ Szentágothai
Oct 27, 2009·Progress in Neurobiology·Tomas Hökfelt
Jul 1, 2010·The Journal of Comparative Neurology·Wenyu FuTomas Hökfelt
Dec 1, 1981·Journal of Neurochemistry·E H Jaffé, A C Cuello
Jun 10, 2003·Nutritional Neuroscience·K S Bedi
Oct 19, 1981·Brain Research·J M PalaciosM J Kuhar
Apr 16, 1986·Brain Research·G A Bishop, J S King

Citations

Apr 22, 1977·Brain Research·C E RibakE Roberts
Oct 1, 1975·The Journal of Physiology·T V Getchell, G M Shepherd
May 28, 1976·Brain Research·M L TappazM Palkovits
Oct 11, 1974·Nature·R RoskoskiF J Diecke
Nov 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·F A Henn, A Hamberger
Nov 15, 1974·Brain Research·A Neidle, J Kandera
Jul 19, 1972·Nature: New Biology·N G Bowery, D A Brown
May 15, 1973·Life Sciences. Pt. 1: Physiology and Pharmacology·L T Graham
Feb 1, 1970·The Journal of Cell Biology·L Descarries, B Droz
Jan 1, 1966·Experimental Neurology·W RallM W Brightman

Related Concepts

Axonal Transport
Cerebellar Mossy Fibers
Neuroglia
Accessory Olfactory Bulb
Axon
Synapses
Premedication
Dendrites
Functional Cerebral Localization
Autoradiography

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Synapse Loss as Therapeutic Target in MS

As we age, the number of synapses present in the human brain starts to decline, but in neurodegenerative diseases this occurs at an accelerated rate. In MS, it has been shown that there is a reduction in synaptic density, which presents a potential target for treatment. Here is the latest research on synapse loss as a therapeutic target in MS.

Artificial Intelligence in Cardiac Imaging

Artificial intelligence (ai) techniques are increasingly applied to cardiovascular (cv) medicine in cardiac imaging analysis. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

Social Learning

Social learning involves learning new behaviors through observation, imitation and modeling. Follow this feed to stay up to date on the latest research.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Single Cell Chromatin Profiling

Techniques like ATAC-seq and CUT&Tag have the potential to allow single cell profiling of chromatin accessibility, histones, and TFs. This will provide novel insight into cellular heterogeneity and cell states. Discover the latest research on single cell chromatin profiling here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells.