Transmural action potential repolarization heterogeneity develops postnatally in the rabbit

Journal of Cardiovascular Electrophysiology
Salim F Idriss, Patrick D Wolf

Abstract

In the hereditary long QT syndrome, arrhythmia risk changes with age despite the presence of an ion channel mutation throughout development. Age-dependent changes in the transmural dispersion of repolarization may modulate this vulnerability. We recorded cardiac action potentials in infant, periadolescent, and adult rabbit myocardium to determine if transmural heterogeneities in repolarization are developmentally determined. Arterially perfused ventricular preparations were studied from 2-week (n = 7), 7-week (n = 7), and adult (n = 6) NZW rabbits. Action potentials were recorded with microelectrodes in five regions: epicardium (epi), subepicardium (subepi), midwall (mid), subendocardium (subendo), and endocardium (endo) during endocardial S1 pacing at cycle lengths of 2,000, 1,000, and 500 ms. At 2 weeks, the transmural APD90 profile was flat. With age, APD prolongation from subepi to endo created a transmural repolarization gradient. At 7 weeks, APD90 was significantly longer at subendo [204 +/- 2 ms (mean +/- SE) 2,000-ms cycle length, P < 0.05] vs both endo (193 +/- 2 ms) and epi (172 +/- 2 ms), causing a heterogeneous transmural APD90 gradient. In adults, the transmural gradient was a smooth continuum such that APD was sho...Continue Reading

References

Oct 1, 1983·Pflügers Archiv : European journal of physiology·N I KukushkinE A Sosunov
May 1, 1993·British Heart Journal·L T ChowJ A Gosling
Feb 1, 1997·Cardiovascular Research·A Rodríguez-SinovasJ Soler-Soler
Jun 13, 1998·Pflügers Archiv : European journal of physiology·P S HaddockW A Coetzee
Mar 25, 1999·Journal of Cardiovascular Electrophysiology·E P AnyukhovskyM R Rosen
Jan 15, 2000·Journal of Cardiovascular Electrophysiology·D M Roden, P M Spooner
Jul 17, 2001·American Journal of Physiology. Heart and Circulatory Physiology·A C ZygmuntC Antzelevitch
Jan 5, 2002·Basic Research in Cardiology·C Antzelevitch, J Fish
Jan 6, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Steven PoelzingDavid S Rosenbaum

❮ Previous
Next ❯

Citations

Nov 24, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Ann M PitruzzelloSalim F Idriss
Apr 28, 2012·Journal of Molecular and Cellular Cardiology·Eman S H Abd AllahMark R Boyett
Sep 25, 2007·Journal of Pharmacological and Toxicological Methods·Motohiro ShiotaniIkuo Horii
May 10, 2005·Journal of Cardiovascular Electrophysiology·Arash Arya
Dec 12, 2007·British Journal of Pharmacology·D A Saint
Aug 19, 2006·IEEE Transactions on Bio-medical Engineering·Salim F Idriss, Ann M Pitruzzello
Apr 8, 2015·International Journal for Numerical Methods in Biomedical Engineering·L E PerottiW S Klug
Dec 20, 2005·Journal of the American College of Cardiology·Jeffrey M FishCharles Antzelevitch
Jul 14, 2011·Progress in Biophysics and Molecular Biology·Lucía RomeroJosé M Ferrero
Sep 29, 2011·Biophysical Journal·Kathleen S McDowellNatalia A Trayanova
Dec 11, 2014·PloS One·Shankarjee KrishnamoorthiAlan Garfinkel
Jun 24, 2016·Progress in Biophysics and Molecular Biology·Hermenegild J ArevaloNatalia A Trayanova
Jun 15, 2007·Circulation·Darwin JeyarajDavid S Rosenbaum
Oct 5, 2007·Progress in Biophysics and Molecular Biology·Thushka MaharajBlanca Rodriguez

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.