PMID: 1259684Jan 1, 1976

Transmural differences in myocardial blood flow and in coronary dilatory capacity in hemodiluted conscious dogs

Basic Research in Cardiology
J HoltzE Mayer

Abstract

In 16 conscious resting dogs regional myocardial blood flow and the local coronary dilatory capacity were studied with the particle distribution technique during isovolemic hemodilution (hct = 13%). Postischemic peak coronary hyperemia following release of temporary circumflex coronary artery occlusion was used for quantification of regional coronary dilatory capacity. In hemodilution (arterial blood oxygen content less than one third of normal) left ventricular blood flow (LVBF) was 460 +/- 36 ml/100 g - min, subendocardial/subepicardial flow amounted to 1.3 +/- 0.1. During postischemic peak hyperemia LVBF increased by 33% up to 606 +/- 63 ml/100 g - min. This 33% increase in LVBF was distributed mainly to the subepicardial layer, while in the subendocardial layer there was no significant flow increase. It is concluded that the increase in heart rate and systolic coronary vascular compression in addition to the lowered arterial oxygen content lead to exhaustion of the dilatory reserve in the subendocardium during hemodilution. Therefore the remaining overall dilatory capacity is without functional significance.

References

Jan 1, 1975·Pflügers Archiv : European journal of physiology·W von RestorffE Bassenge
Jan 1, 1975·Pflügers Archiv : European journal of physiology·W von RestorffE Bassenge
Jan 1, 1973·Basic Research in Cardiology·W SchaperL Gijpen
Jul 1, 1974·Basic Research in Cardiology·B WüstenW Schaper
Jan 1, 1973·Pflügers Archiv : European journal of physiology·U FinstererH Brechtelsbauer
Jan 1, 1973·Advances in Experimental Medicine and Biology·G D Buckberg, A A Kattus
Mar 1, 1974·Circulation Research·J M DowneyE S Kirk
Aug 1, 1974·Journal of Applied Physiology·D E FixlerD Huffines
Oct 1, 1971·Journal of Applied Physiology·G D BuckbergD E Fixler
Sep 1, 1964·The American Journal of Physiology·W W MYERS, C R HONIG
Feb 1, 1965·Circulation Research·D E GREGGC R RAYFORD
Feb 1, 1965·The American Journal of Physiology·R A OLSSON, D E GREGG

Citations

Jul 1, 1979·Hypertension·S P BishopJ L Drummond
Oct 2, 2017·Basic Research in Cardiology·Alexander M KielJohnathan D Tune
Sep 16, 1977·Pflügers Archiv : European journal of physiology·J HoltzE Bassenge
Aug 5, 2008·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·George J CrystalSong-Jung Kim
Dec 12, 1977·Pflügers Archiv : European journal of physiology·W von RestorffE Bassenge

Related Concepts

Metazoa
Arteries
Coronary Circulation
Canis familiaris
Pulse Rate
Left Ventricular Structure
Dioxygen
Plasma Substitutes
Coronary Heart Disease
Canis familiaris

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