PMID: 7547185Feb 1, 1995Paper

Transmural distribution of 2-deoxyglucose uptake in normal and post-ischemic canine myocardium

NMR in Biomedicine
M YoshiyamaJ Zhang

Abstract

This investigation was performed to determine (i) whether 31P spatially localized 31P NMR spectroscopy could be utilized to determine the transmural distribution of 2-deoxyglucose (2DG) uptake in the in vivo canine heart and (ii) whether transmural 2DG uptake would be affected by a preceding ischemic insult. 2DG was infused and the accumulation of 2-deoxyglucose-6-phosphate (2DGP) was monitored (by means of spatially localized 31P NMR) in control hearts, in pharmacologically hyperperfused hearts, and in hearts subjected to four (5 min) occlusions of the left anterior descending coronary artery. Myocardial blood flow was measured with radioactive microspheres. In control hearts, subendocardial (ENDO) 2DGP contents were significantly higher than those in the subepicardium (EPI) being 3.8 +/- 0.3 and 2.2 +/- 0.2 mumol/g, respectively; the ENDO/EPI ratio of 2DGP was 1.70 +/- 0.21. During hyperperfusion blood flow increased approximately four-fold but 2DGP accumulation was not altered. ATP levels in post-ischemic myocardium were significantly decreased (ENDO more than EPI) and 2DGP accumulation in each layer was increased (p < 0.01 vs control); however, the ENDO/EPI ratio of 2DGP was not altered. 2DG infusion induced a marked elevat...Continue Reading

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Citations

Apr 22, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Mohammad N JameelJianyi Zhang
Sep 11, 2001·Journal of Molecular and Cellular Cardiology·R B JenningsK A Reimer
Dec 21, 2000·American Journal of Physiology. Heart and Circulatory Physiology·Y K ChoK Ugurbil
Jul 19, 2000·American Journal of Physiology. Heart and Circulatory Physiology·J A FallavollitaJ M Canty
Oct 24, 2002·Journal of Molecular and Cellular Cardiology·Lionel H Opie, Michael N Sack

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