PMID: 6403921Jan 1, 1983Paper

Transmural gradient of glycogen metabolism in the normal rat left ventricle

Pflügers Archiv : European journal of physiology
V De TataE Bergamini

Abstract

The changes of glycogen metabolism with the location of tissue within the ventricle wall have been explored in the rat myocardium. The hearts were cut in 100 microns thick serial sections and all sections were analyzed for their content in glycogen, glucose-6-phosphate, UDPG and glycogen enzymes and for glucose incorporation into glycogen and for the 2-deoxyglucose uptake after the intravenous injection of the 14C-labelled sugars. The rate of glycogen turnover was significantly higher in the subendocardial myocardium (P less than 0.01) and the levels of glucose-6-phosphate and the total (i.e. a + b) activity of glycogen phosphorylase were significantly higher in the subepicardial tissue (P less than 0.01 in both instances). No significant transmural gradient of UDPG was found and transmural changes of total (i.e. I + D) synthase activity were barely significant. These changes in glycogen metabolism may be related to regional differences in the cardiac work load and to a differentiation of the subendocardial and subepicardial heart fibers.

References

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Citations

Jun 8, 1971·Life Sciences. Pt. 2: Biochemistry, General and Molecular Biology·E BergaminiC Pellegrino
Jan 1, 1986·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·V De TataE Bergamini
Mar 15, 1996·The Journal of Clinical Investigation·G W GoodwinH Taegtmeyer
Mar 1, 1991·Aging : Clinical and Experimental Research·A Del RosoE Bergamini
Aug 1, 1990·Pflügers Archiv : European journal of physiology·V De TataE Bergamini
Aug 30, 2008·Neurochemical Research·Heide SchmidBernd Hamprecht
Jan 1, 1991·International Journal of Radiation Applications and Instrumentation. Part B, Nuclear Medicine and Biology·M RubartN Hahn
Apr 15, 1996·Circulation·S L HenningM F Allard

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