Transnasal Humidified Rapid Insufflation Ventilatory Exchange in children requiring emergent intubation (Kids THRIVE): a protocol for a randomised controlled trial

BMJ Open
Shane GeorgePaediatric Critical Care Research Group (PCCRG), Paediatric Research in Emergency Departments International Collaborative (P

Abstract

Emergency intubation of children with abnormal respiratory or cardiac physiology is a high-risk procedure and associated with a high incidence of adverse events including hypoxemia. Successful emergency intubation is dependent on inter-related patient and operator factors. Preoxygenation has been used to maximise oxygen reserves in the patient and to prolong the safe apnoeic time during the intubation phase. Transnasal Humidified Rapid Insufflation Ventilatory Exchange (THRIVE) prolongs the safe apnoeic window for a safe intubation during elective intubation. We designed a clinical trial to test the hypothesis that THRIVE reduces the frequency of adverse and hypoxemic events during emergency intubation in children and to test the hypothesis that this treatment is cost-effective compared with standard care. The Kids THRIVE trial is a multicentre randomised controlled trial performed in participating emergency departments and paediatric intensive care units. 960 infants and children aged 0-16 years requiring emergency intubation for all reasons will be enrolled and allocated to THRIVE or control in a 1:1 allocation with stratification by site, age (<1, 1-7 and >7 years) and operator (junior and senior). Children allocated to THRI...Continue Reading

References

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Citations

Dec 14, 2019·Paediatric Anaesthesia·Susan Humphreys, Andreas Schibler
Dec 31, 2019·Paediatric Anaesthesia·Gillian R LauderThomas Engelhardt
Sep 25, 2020·Emergency Medicine Australasia : EMA·Shane GeorgeUNKNOWN Paediatric Critical Care Research Group (PCCRG), Australian and New Zealand Intensive Care Society Paediatric Study Group (A

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Software Mentioned

THRIVE

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